|Category||Biochemistry & Molecular Biology|
|Keywords||MMPs mesh smooth muscle function|
|Target Audience||Urogynecologists, urologists, PhD students, PhDs, fellows, graduate students|
|Aims and Objectives|
This workshop will update and educate participants on the latest research into the pathogenesis and treatment of pelvic organ prolapse. Talks on pathogenesis will cover intrinsic differences in connective tissue remodeling in women with and without prolapse that favors a degradative response in the former and not the latter. In addition, mechanisms by which maternal birth injury alters the loading environment of the vagina and predisposes to prolapse will be explored. Attendees will learn the appropriateness of different animal models to study prolapse. Finally, the host response to the surgical repair of prolapse using biological vs synthetic meshes will be reviewed as well as a functional approach to selecting a mesh product.