Bladder Physiology and Application

Workshop 12

Workshop Schedule

14:00

Longkun Li

14:05

Sivert Lindstrom

14:30

Longkun Li

15:00

All

15:10

Chonghe Jiang

Aims & Objectives

Basic
90 minutes
Cellular Physiology
HCN channel bladder interstitial cell of Cajal
urologists

Because the urinary bladder can contract voluntarily through myogenic excitation, it would be reasonable to predict that the bladder has the potential for self-excitation. The physiological effects of the hyperpolarization-activated nucleotide-gated (HCN) channel in initiating and modulating bladder excitability need to be investigated. Moreover, the interstitial cells of Cajal (ICCs) in the bladder have been suggested to participate in the bladder pacemaking and signal transmission. However, the relationship between the ICCs and HCN channels needs to be clarified. In this study, the HCN channel and its subtypes in the bladder, as well as their relationships to the bladder ICCs, were investigated.