Study design, materials and methods
The charts of all PD patients who underwent videourodynamics (VUD) for storage symptoms between 2010 and 2017 at a single academic neurourology division were retrospectively reviewed. Patients in which VUD was indicated for OAB symptoms were included in the present study. Means and standard deviations were reported for continuous variables and proportions for nominal variables. Univariate analyzes using Fisher exact test or chi-2 test for nominal variables and Mann-Whitney test for continuous variables were performed to seek for clinical predictive factors of various urodynamic parameters.
Results
Forty-two patients were included in the present analysis. On VUD, 41 of the 42 patients had an involuntary detrusor contraction (IDC) (97.6%). The one patient who did not have an IDC was diagnosed with PD only 2 months prior to her VUD study. The mean volume of the 1st uninhibited contraction was 168.2ml. The first desire to void occurred on average at 139.5 ml with an average cystometric capacity of 274.8ml. On pressure flow analysis, the patients had an average maximum flow of 10.2 ml/s, with an average detrusor pressure at maximum flow of 36.2 cm H2O. The maximum detrusor pressure was 53.7 cmH2O. The average voided volume was 141.3 ml. When analyzing differences among gender, detrusor pressure at maximum flow was significantly higher in males than females (41.3 vs 22.6, p=0.001).
Interpretation of results
Most PD patients with OAB symptoms exhibit DO. The decision to perform urodynamics in these patients should be prompted by other objectives than diagnosing DO because this urodynamic finding can be presumed with a very high probability from clinical observation.