Voiding Profile in Post Renal Transplantation Patient

Parikesit D1, Widia F1, Rahardjo H1

Research Type

Clinical

Abstract Category

Overactive Bladder

Abstract 569
E-Poster 3
Scientific Open Discussion Session 31
Friday 6th September 2019
13:35 - 13:40 (ePoster Station 2)
Exhibition Hall
Prospective Study Quality of Life (QoL) Overactive Bladder Questionnaire
1.Urology Department, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Presenter
F

Fina Widia

Links

Poster

Abstract

Hypothesis / aims of study
Background: Renal transplantation (RTX) was though to have higher survival rates, quality of life (QoL), cost effective, and better clinical results compare to renal replacement therapy (RRT) such dialysis. However, patients with chronic kidney disease (CKD)  and long term dialysis may have decrease bladder function due to disuses. The aim of this study is to evaluate voiding characteristics of recipient after renal transplant surgery.
Study design, materials and methods
Materials & method: Seventy-one patients were diagnosed with CKD and transplanted from living donor in a single center. Anthropometric parameters, physical examinations, cause of CKD, daily urine production, types and duration of dialysis, and basic laboratory examination were collected before transplant surgery. While, post-operative laboratory examination, international prostate symptom score (IPSS), for male patients only, Overactive bladder symptom score (OABSS), uroflowmetry, and post void residue (PVR) was gathered after surgery.
Results
Result: seventy-one patients were evaluated with mean age of 46 ± 17.9 years old with male and female ratio of 52:19. Significant negative correlation was seen between duration of dialysis and daily urine production (r: -0.68, p<0.01). Majority of patients have Qmax more than 15 cc/s (70.4 %) with average flow of 22 ± 9.8 cc/s. Majority of patients had PVR less than 100 cc (91.5 %) with median PVR of 33.5 cc (2.3 – 142). IPSS result shows that frequency [2 (0 – 5)] and nocturia [2 (0 – 5)] are the main problem in these patients (n: 52). OABSS questionnaire also shows that frequency (OABSS 1) and nocturia (OABSS 2) was the main symptom reported by patient, with score 1 (0 – 2) and 2 (0 – 3), respectively.
Interpretation of results
According to IPSS and OABSS questionnaire, the main symptoms experience with patients after RTX was frequency and nocturia, respectively. Regardless of this fact, majority of patients QoL were not affected; 94.2 % of all patients were pleased after RTX due to the fact that they do not need Renal Replacement Therapy (RRT).
Concluding message
Conclusion: After RTX, majority of patients experienced frequency and nocturia problem due to various causes such as increase daytime and nighttime urine production, urinary tract infection, bladder capacity (both small and large), decrease bladder compliance.
Disclosures
Funding Dyandra Parikesit, Fina Widia, and Harrina Erlianti Rahardjo declare that there are no conflict of interest regarding the research. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1964 and its later amendments. Informed consent was obtained from all patients for being included in the study. Clinical Trial No Subjects Human Ethics Committee Prof. Rianto Setiabudy, Md, PhD. Helsinki Yes
19/04/2024 05:12:59