Study design, materials and methods
We conducted a big data analysis on the association between LUTS and fractures in community-dwelling older men. Elderly patients (≥ 65 years old) in 2013, 2014, 2015, 2016 were included from the Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS). We used 2013, 2014, 2015, 2016 HIRA-APS, respectively. We classified four groups: alpha-blocker (group A), alpha-blocker + 5 ARI, alpha-blocker + β3-agonist (group B) or antimuscarinic agents (group C) and control group. We excluded previous fracture event before medications.
Only alpha-blocker group was observed least event of fracture in total cohort every years (p <0.001). And patients with large prostate volume were similar or worse pattern of fracture event compared with control (p = 0.36, 1, 1, 0.008, respectively). Moreover, patients with storage symptoms were shown worst results of fracture (p = 0.003, 0.38, 0.002, 1, respectively).
Interpretation of results
Lower urinary tract storage symptoms might be associated with fracture in older men.