Lower urinary tract symptoms (LUTS) have been associated with falls and fracture predominantly in women. It is less clear if LUTS are risk of fracture in men. We evaluated the relation between LUTS and fracture in men.

We conducted a big data analysis on the association between LUTS and fractures in community-dwelling older men. Elderly patients (≥ 65 years old) in 2013, 2014, 2015, 2016 were included from the Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS). We used 2013, 2014, 2015, 2016 HIRA-APS, respectively. We classified four groups: alpha-blocker (group A), alpha-blocker + 5 ARI, alpha-blocker + β3-agonist (group B) or antimuscarinic agents (group C) and control group. We excluded previous fracture event before medications.

Only alpha-blocker group was observed least event of fracture in total cohort every years (p <0.001). And patients with large prostate volume were similar or worse pattern of fracture event compared with control (p = 0.36, 1, 1, 0.008, respectively). Moreover, patients with storage symptoms were shown worst results of fracture (p = 0.003, 0.38, 0.002, 1, respectively).

Lower urinary tract storage symptoms might be associated with fracture in older men.

Lower urinary tract storage symptoms might be associated with fracture in older men. It could be associated with falls. The circumstances of falls in men with LUTS need to be investigated to reduce falls and fracture.

Noguchi N, Chan L, Cumming RG, Blyth FM, Naganathan V. A systematic review of the association between lower urinary tract symptoms and falls, injuries, and fractures in community-dwelling older men.Aging Male. 2016 Sep;19(3):168-174.