A big data analysis of the association between lower urinary tract symptoms and fractures in older men.

Jo J1, Kim K1, Moon H1

Research Type

Clinical

Abstract Category

Male Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 786
Non Discussion Abstract
Scientific Non Discussion Abstract Session 37
Urgency/Frequency Male Outcomes Research Methods
1.Department of Urology, Hanyang University College of Medicine, Seoul, Korea
Links

Abstract

Hypothesis / aims of study
Lower urinary tract symptoms (LUTS) have been associated with falls and fracture predominantly in women. It is less clear if LUTS are risk of fracture in men. We evaluated the relation between LUTS and fracture in men.
Study design, materials and methods
We conducted a big data analysis on the association between LUTS and fractures in community-dwelling older men. Elderly patients (≥ 65 years old) in 2013, 2014, 2015, 2016 were included from the Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS). We used 2013, 2014, 2015, 2016 HIRA-APS, respectively. We classified four groups: alpha-blocker (group A), alpha-blocker + 5 ARI, alpha-blocker + β3-agonist (group B) or antimuscarinic agents (group C) and control group. We excluded previous fracture event before medications.
Results
Only alpha-blocker group was observed least event of fracture in total cohort every years (p <0.001). And patients with large prostate volume were similar or worse pattern of fracture event compared with control (p = 0.36, 1, 1, 0.008, respectively). Moreover, patients with storage symptoms were shown worst results of fracture (p = 0.003, 0.38, 0.002, 1, respectively).
Interpretation of results
Lower urinary tract storage symptoms might be associated with fracture in older men.
Concluding message
Lower urinary tract storage symptoms might be associated with fracture in older men. It could be associated with falls. The circumstances of falls in men with LUTS need to be investigated to reduce falls and fracture.
Figure 1
References
  1. Noguchi N, Chan L, Cumming RG, Blyth FM, Naganathan V. A systematic review of the association between lower urinary tract symptoms and falls, injuries, and fractures in community-dwelling older men.Aging Male. 2016 Sep;19(3):168-174.
Disclosures
Funding none Clinical Trial No Subjects Human Ethics not Req'd this reaserch is based on data analysis Helsinki Yes Informed Consent No