ICS 2020 Scientific Podium Short Oral Session S24

Sensory Function and Fibrosis

Scientific Podium Short Oral Session S24

This content is intended for health care providers only.

Speakers
	On-Demand
L Lori A Birder ICS Chair G Georgi Petkov ICS Chair

Session Schedule

#366 Is soluble VEGFR1 a putative biomarker and therapeutic target for BPS/IC?

Ribeiro-Oliveira R¹, Mendes P², Manso M³, Pinto R², Cruz F², Charrua A¹
1. I3S and FMUP, 2. FMUP, I3S, CHSJ, 3. CHSJ
Painful Bladder Syndrome/Interstitial Cystitis (IC), Female, Basic Science

#367 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONIST AS A NOVEL TREATMENT FOR INTERSTITIAL CYSTITIS: A RAT MODEL

Comiter C¹, Dobberfuhl A¹, Mahal A²
1. Stanford University, 2. University of Nebraska
Painful Bladder Syndrome/Interstitial Cystitis (IC), Voiding Dysfunction , Pain, Pelvic/Perineal, Animal Study

#368 Effects of a soluble guanylate cyclase activator, BAY 60-2770, on neurogenic lower urinary tract dysfunction in mice with spinal cord injury

Gotoh D¹, Saito T¹, Kurobe M¹, Igarashi T¹, Singh N¹, Miyake M², Torimoto K², Fujimoto K², Yoshimura N¹
1. University of Pittsburgh, 2. Nara Medical University
Animal Study, Detrusor Overactivity, Pharmacology, Physiology, Spinal Cord Injury

#369 NERVE GROWTH FACTOR PRECURSOR (PRONGF) EXERTS DIFFERENT BIOLOGICAL ACTIONS ON UROTHELIAL AND SMOOTH MUSCLE CELLS OF RODENTS BLADDERS.

Mossa A¹, Cammisotto P², Campeau L³
1. McGill University, 2. Lady Davis Institute, 3. Jewish General Hospital, McGill University
Basic Science, Cell Culture, Molecular Biology, Pathophysiology, Neuropathies: Peripheral

#370 Inhibiting miR-21-5p alleviates bladder fibrosis and detrusor overactivity in spinal cord injured rats

Shang Z¹, Ou T¹
1. Xuanwu Hospital Capital Medical University
Spinal Cord Injury, Animal Study, Detrusor Overactivity, Basic Science

#371 Sex differences in bladder wall fibrosis and compliance in spinal cord transected mice—role of angiotensin signalling

Zabbarova I¹, Ikeda Y¹, Kozlowski M¹, Birder L¹, Fry C², Kanai A¹
1. University of Pittsburgh, 2. University of Bristol
Spinal Cord Injury, Basic Science, Animal Study

#372 Losartan prevents bladder fibrosis and protects renal function in rats with neurogenic bladder

Wen J¹, He Y¹, Pu Q¹, Wen Y¹, Zhai R¹, Ma Y¹, Liu E¹, Xing D¹, Ji F¹, Yang X¹
1. Pediatric Urodynamic Centre, Department of Urology, the First Affiliated Hospital of Zhengzhou University, China
Animal Study, Underactive Bladder, Neuropathies: Central

#373 Urothelial lysosomal dysfunction causes bladder hyperactivity and inflammation

Rodriguez R¹, Phipps S¹, Obidike C¹, Daugherty S¹, Beckel J¹
1. University of Pittsburgh, PA USA
Painful Bladder Syndrome/Interstitial Cystitis (IC), Molecular Biology, Urgency/Frequency, Voiding Dysfunction , Overactive Bladder

#374 Acid-sensing ion channel 3 (ASIC3) inhibitor increases functional bladder capacity with or without acidic irritation of lower urinary tract in mice when administering intraperitoneally but not intravesically

Yoshiyama M¹, Kobayashi H², Araki I³, Takeda M⁴
1. Shintotsuka Hospital, 2. Kobayashi Urology Clinic, 3. Koka Office of Public Health and Welfare, 4. University of Yamanashi
Basic Science, Animal Study, Painful Bladder Syndrome/Interstitial Cystitis (IC)

#375 Mast cell tryptase causes lower urinary tract dysfunction associated with chronic ischemia

Akaihata H¹, Yoshida Y¹, Imai H¹, Meguro S¹, Honda R¹, Matsuoka K¹, Hoshi S¹, Hata J¹, Sato Y¹, Kataoka M¹, Ogawa S¹, Haga N¹, Kojima Y¹
1. Fukushima Medical University
Animal Study, Overactive Bladder, Prevention

#376 Long-lasting bladder hypersensitivity with frequent urination induced by intravesical application of of hydrogen peroxide in rats with pelvic venous congestion

Suzuki T¹, Mizoguchi S², Kurobe M², Saito T², Takaoka E², Kishida T³, Yao M⁴, Yoshimura N²
1. University of Pittsburgh, Kanagawa Cancer Center, 2. University of Pittsburgh, 3. Kanagawa Cancer Center, 4. Yokohama City University
Animal Study, Painful Bladder Syndrome/Interstitial Cystitis (IC), Urgency/Frequency, Basic Science

#377 A pilot animal model to identify the intravesical bladder irritant cystometric dose response threshold for six common environmental exposures associated with overactive and painful bladder dysfunction in humans with IC/BPS

Shenhar C¹, Dobberfuhl A²
1. Rabin Medical Center, Div. of Urology, 2. Stanford University, Dept. of Urology
Animal Study, Basic Science, Painful Bladder Syndrome/Interstitial Cystitis (IC)

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