Urinary incontinence analysis in pregnant women using IIQ-7 and UDI-6

Loposso N1, Mosolongo Y1, Nkodila G1, Esika M1, Punga-Maole M1, Mbey P1, Diangienda K1, Mbala B1, Lebugh G1, Moningo M1, Mafuta A1, Dirk D2

Research Type

Clinical

Abstract Category

Female Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 112
Open Discussion ePosters
Scientific Open Discussion Session 7
Thursday 8th September 2022
12:50 - 12:55 (ePoster Station 4)
Exhibition Hall
Female Questionnaire Quality of Life (QoL)
1. Kinshasa University, 2. Kuleuven
In-Person
Presenter
N

Nkumu Matthieu Loposso

Links

Poster

Abstract

Hypothesis / aims of study
Urinary incontinence(UI) in pregnant women have various rates: 7 to 64%. The variability of this rate is related to the heterogeneous inclusion criteria and  urinary incontinence   definition(1). Most of these prevalence’s are   described in Europe and the USA.
Thus, the universal database   enrichment and up  date   required this study   initiation.  The aim  was firstly,   to characterize pregnant  women who had urinary incontinence socio-demographically; secondly, to describe  clinical presentation as well as the risk factors associated with UI in pregnant women through the use of IIQ-7 and UDI-6(2).
Study design, materials and methods
This is an analytical cross-sectional study.
2.1. Sampling:  -The study population  consisted of all the women seen in surgery consultation. They have been selected in such a way as to meet the specific needs of the study hypothesis.
    Selection criteria: Any woman who was at least 18 years old and freely agreed in writing or orally to participate in the study was included. Women with known mental disorders and those in a state of unconsciousness were not included in these surveys. Women who did not answer two-thirds of the questionnaire during the survey were excluded from the study.
* Data collection: The data collection methods were based on semi-structured face-to-face anonymous and confidential interviews by the use of a standard questionnaire containing a number of themes that was developed and submitted to the respondent. They confirmed their agreement by signing a consent form. Each interview lasted between 5 and 10 minutes.
*The interest variables :- socio-demographic characteristics including: age, education level and medical training; - clinical characteristics and morbid history: gynecological identity (PGA), weight, height, tobacco consumption , alcohol, constipation, physical activity, chronic cough and pelvic surgery.- Factors favoring UI: cold, cough, defecation, coffee, sealing, alcohol.- UDI-6 and IIQ-7 score variables(3).
The diagnosis of UI was made on   basis of urinary incontinence diagnosis. 6 questions formed the basis of the diagnosis grouped in the form of the UDI-6. Thus, taking into account the total obtained from the UDI-6 score; urinary incontinence was categorized in terms of severity into the following 4 stages:- score between 0-2: minimal incontinence.- score between 3-6: moderate incontinence.- score between 7-9: severe incontinence.- Score ≥ 10: very severe incontinence
Quality of life was assessed using the IIQ-7 score. As for the UDI-6 score, the sum of the IIQ-7 score made it possible to classify the women into 3 groups:- low risk of handicap if the score 0-2;- moderate risk of handicap if the score 3-9- risk of severe disability if the score ≥10.
 Statistical Analysis: - After data collection; an initial quality control was carried out in the field to ensure completeness; data accuracy and reliability. A second consistency check of each sheet was carried out to report corrections to certain inconsistencies noted in order to guarantee the results validity.
- The descriptive analyzes carried out are the mean and the standard deviation for the quantitative data with Gaussian distribution and the relative (%) and absolute (n) proportions for the categorical or qualitative data.
- Pearson's chi-square or exact file test, as the case may be, was carried out to compare the percentages and the Student's t test compared the means.
- The linear regression test was used to look for linear associations between the UDI-6 score and the continuous variables. Urinary incontinence associated factors were sought by the logistic regression test with calculation of the odds ratio (OR) in order to determine the association degree. For all the tests carried out, the value of p < 0.05 was the threshold of statistical significance.
 Ethical considerations: The confidentiality of the respondent was guaranteed because no personal information that could link the respondent to his data was collected.
Results
A total of 1015 women were questione, their average age was 28.9 ± 6.6 years.
 The age group of 20-29 years was the most represented with 45% of cases. Median parity and gestality were 2  and 3 , respectively. The majority of women were pauciparous (35.9%) and 2nd-3rd parous (43.4%). Their weight, height and average BMI were respectively 74.4 ± 12.2 kg, 1.60 ± 0.09 m and 29.1 ± 5.3 kg/m2:
 40.5% were overweight, 5.6% and 38.4% used tobacco and alcohol respectively. Only 28.2% who practiced physical activity and 45% had undergone pelvic surgery.
Among UI factors favoring, the majority were cough (60.3%), cold (47%) and defecation (38.3%).
The women's UDI-6 score was found to increase significantly with increasing age (p=0.001).
There was a positive and significant linear correlation between age and UDI-6 score. This correlation was 49% (r=0.489).
In a multiple linear regression analysis of age, BMI and parity emerged as independent determinants of UDI-6 score, explaining 44% of its variability.
Of the 1015 women questioned, 667 had a very high score, a frequency of UI was 65.7%.
It appears that the majority of women had very severe incontinence (42.1%), followed by moderate incontinence (32.9%).
The UI frequency  was significantly higher in multiparas with a significant difference (p=0.033).
In univariate analysis, the UI determinants   were age ≥40 years, 30-39 years; high school, university level, multigesture, alcohol consumption, physical inactivity, constipation, defecation and drinking emerged as UI determinants. After adjusting for all these variables in a multiple logistic regression, high school, university level, multi-gravity, physical inactivity, constipation and alcohol consumption emerged as UI determinants. 
The simple linear regressions analysis showed a correlation which was positive between the IIQ-7 score and UDI-6, this correlation was 58% (r=0.577)
The factors leading to severe disability were university education level (p<0.001), multigestacy (p=0.026), smoking (p<0.001), physical inactivity (p<0.001), obesity (p=0.008), infection (p<0.001), chronic cough (p=0.020), twin pregnancy (p=0.027), pelvic surgery (p<0.001), macrosomia (p<0.001) and UI (p<0.001
Interpretation of results
In pregnant women, we assert that the UDI-6 score increases with age. This score independent determinants are age, body mass index and parity. The quality of life assessed by IIQ-7 has a positive correlation with the UDI-6 score. University studies, inveterate alcoholism,  physical exercise absence and constipation are linked to the quality of life, therefore to the IIQ-7.
Concluding message
Stress urinary incontinence and urgency assessed by the IIQ7 and UDI-6 are present in pregnant women in relatively high proportions.
Their aggravation presents a similarity (positive correlation) by the use of these two questionnaires.
More research are  needed to explain the involvement of  determinants including quality of life and symptoms alteration  related to UI.
Figure 1 Figure 1. IIQ-7 Score and IDU-6 Correlation in pregnant women
Figure 2 Table 1. Urinary incontinence Determinants in pregnant women
References
  1. Loposso MN, Ndundu J, Mbunzu D, Matala T, Punga AM, De Ridder D. Assessing quality of life in obstetric fistula patients: Validation of the urogenital distress inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) in Lingala and Kikongo in DR Congo. Neurourol Urodyn. 2019 Sep;38(7):1994-2000. doi: 10.1002/nau.24105. Epub 2019 Jul 18. PMID: 31321812.
  2. Saffarini JH, Ahmad QT, Samara AM, Jabri DS, Safarini ZH, Banijaber YM, Jaradat A, Abushamma F, Zyoud SH. Assessment of lower urinary tract symptoms during pregnancy: an observational cross-sectional study from Palestine. BMC Pregnancy Childbirth. 2021 Jan 26;21(1):84. doi: 10.1186/s12884-021-03567-1. PMID: 33499816; PMCID: PMC7836150.
  3. Saffarini JH, Ahmad QT, Samara AM, Jabri DS, Safarini ZH, Banijaber YM, Jaradat A, Abushamma F, Zyoud SH. Assessment of lower urinary tract symptoms during pregnancy: an observational cross-sectional study from Palestine. BMC Pregnancy Childbirth. 2021 Jan 26;21(1):84. doi: 10.1186/s12884-021-03567-1. PMID: 33499816; PMCID: PMC7836150.
Disclosures
Funding None Clinical Trial Yes Registration Number Comité national d' ethiquede la sante numero341/CNES/BN/PMMF/2022 du 13/03/2022 RCT Yes Subjects Human Ethics Committee Comité national d' éthique Helsinki Yes
30/04/2024 21:07:23