Heterogeneity in Outcome Reporting in RCTs of Laparoscopic and Robotic Surgery for Pelvic Organ Prolapse: A Systematic Review

Pagaki C1, Ediripolage F2, Papalois K3, Elfituri A1, Haddad J4, Roman M5, Tsakos E6, Falconi G7, Betschart C8, Doumouchtsis S1

Research Type

Clinical

Abstract Category

Pelvic Organ Prolapse

Abstract 766
Open Discussion ePosters
Scientific Open Discussion Session 108
Friday 9th October 2026
13:50 - 13:55 (ePoster Station 3)
Exhibition Hall
Prolapse Symptoms Pelvic Organ Prolapse Female Surgery Robotic-assisted genitourinary reconstruction
1. Department of Obstetrics and Gynecology, Epsom and St Helier University Hospitals NHS Trust, London, UK, 2. Faculty of Medicine, St George’s University of London, London, UK, 3. Oxford University Hospitals NHS Trust, Oxford, UK, 4. e Department of Obstetrics and Gynecology, Faculty of Medicine, University of Paulo, Sao Paulo, SP, Brazil, 5. 2nd Department of Obstetrics-Gynecology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, 6. EmbryoClinic IVF, Thessaloniki, Greece, 7. Complex Operative Unit of Gynecology, Fondazione Policlinico Tor Vergata University Hospital, Rome, Italy, 8. Department of Gynecology, University Hospital Zurich, University of Zurich, Switzerland
Presenter
Links

Poster

Abstract

Hypothesis / aims of study
Variation in outcome selection and reporting in randomized controlled trials (RCTs) evaluating minimally invasive surgery for pelvic organ prolapse (POP) limits comparability and evidence synthesis. This study aimed to systematically evaluate the range, consistency, and quality of reported outcomes and outcome measures in RCTs of laparoscopic and robotic POP surgery.
Study design, materials and methods
A systematic review was conducted in accordance with PRISMA methodology. Electronic databases (EMBASE, PubMed, and Cochrane CENTRAL) were searched from inception to May 2025.
Eligible studies were randomized controlled trials including adult women undergoing laparoscopic or robotic surgical interventions for POP. Data extracted included study characteristics, reported outcomes, and outcome measures.
Outcomes were grouped into domains and overarching themes. Methodological quality was assessed using the Jadad score, while outcome reporting quality was evaluated using MOMENT criteria. Correlation analyses were performed to explore associations between reporting quality and study characteristics.
Results
Forty-five RCTs involving 4,566 women were included. A total of 83 distinct outcomes and 59 outcome measures were identified, grouped into 12 domains.
The most frequently reported outcomes were operative time (60–65%), blood loss (~60%), postoperative pain (~50%), quality of life (~50%), and anatomical success (~60%). However, substantial heterogeneity was observed in outcome definitions, reporting frequency, and measurement tools.
Patient-reported outcomes were assessed in most studies, but with marked variability, particularly in quality-of-life measures, where 24 different instruments were used. The POP-Q system was the most consistently applied objective measure.
Important patient-centered outcomes such as sexual function, cosmesis, and cost were infrequently reported. Definitions of surgical success and recurrence varied considerably across studies.
Methodological quality was moderate overall, and no strong correlation was found between reporting quality and journal impact factor or study characteristics.
Interpretation of results
Outcome reporting in RCTs of minimally invasive POP surgery is highly heterogeneous, particularly for patient-reported and long-term outcomes. This variability limits comparability across studies and complicates meta-analysis and evidence-based decision-making.
The underrepresentation of patient-centered outcomes highlights a misalignment between research reporting and patient priorities.
Concluding message
There is a clear need for standardization of outcome selection and reporting in POP surgery trials. Development and implementation of core outcome sets will improve comparability, enhance research quality, and support patient-centered care.
Disclosures
Funding None Clinical Trial No Subjects None AI For simple textual assistance in writing the abstract manuscript
11/10/2026 07:02:09