Nitric oxide (NO) bioavailability diminishes with age secondarily to oxidative stress, and is considered to play an important role in arterial function impairment in older individuals. Behavioral changes such as aerobic exercise and chronic caloric restriction have been shown to effectively reduce oxidative stress and, therefore, ameliorate the aging-related decrease in NO bioavailability. Skeletal muscle undergoes a progressive age-related loss in mass and function. This reduction may be due to the reduced satellite cell migration observed in aged muscle. NO has been shown to reverse satellite cells migration speed loss, suggesting that drugs that increase NO bioavailability may prevent muscle mass loss with age. Drugs that modulate NO bioavailability such as statins, resveratrol and hormones (estrogen and dehydroepiandrosterone) have been proposed as possible tools in treating/ preventing aging-related vascular dysfunction.