This state of the art lecture will cover the 'increasing evidence that has pointed to a relationship between LUTS and the presence of metabolic syndrome. The prevalence of obesity (BMI > 30) is markedly low in Asia, however, there is no difference in the prevalence of OAB between Asian countries and US & European countries. This lecture will review and emphasise lifestyle factors/diseases, which have a major influence on the development of LUTS. Understanding the underlying relationship between lifestyle factors and LUTS may lead to the development of new strategies for preventing and/or treating LUTS.'