The age-dependent prevalence and severity of urinary incontinence after one pregnancy and one vaginal delivery and the attributable risk reduction with C-section

Gyhagen M1, Åkervall S1, Othman J A1, Nilsson I1, Milsom I1

Research Type

Clinical

Abstract Category

Female Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 624
Epidemiology and Prevention
Scientific Podium Short Oral Session 30
Friday 31st August 2018
14:22 - 14:30
Hall C
Incontinence Prevention Pelvic Floor Female
1. Gothenburg Continence Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
Presenter
M

Maria Gyhagen

Links

Abstract

Hypothesis / aims of study
The relative importance of pregnancy per se, vaginal delivery, and the potential protective effect of cesarean section on the prevalence of urinary incontinence (UI) in the long-term are still unresolved and controversial issues. The aim of this study was to compare the age-dependent prevalence and severity of different aspects of UI in women aged between 40 and 65 years after one pregnancy and one vaginal delivery, and the attributable risk reduction of UI with C-section.
Study design, materials and methods
Three randomly selected national cohorts (nulliparous women, one-para women with a vaginal birth and one-para women with cesarean delivery, n = 14 335) were studied. Nulliparous women were obtained by Statistics Sweden. One-para, vaginally and cesarean delivered women were recruited from the Swedish Medical Birth Register and surveyed 20 years after birth. Self-administered, validated questionnaires for different aspects of UI, using the IUGA/ICS definitions (1) and Sandvik’s severity index (2), were used. The effect of one pregnancy and one vaginal delivery was analyzed with one-to-one matched cohorts. Matching sought to balance for body mass index and age, shown to be strong confounders of UI (3).
Results
The logistic regression model showed that the age-related gap for UI between nulliparous and 1-para women delivered vaginally or by cesarean section was constant between parallel trajectories that spanned between the ages of 40 and 65 years (Figure 1). Pregnancy increased the overall prevalence of UI from 20.1% to 30.1% (OR1.71, 95%CI 1.43-2.05; p<0.0001) and vaginal delivery increased the overall UI prevalence from 30.1% to 43.0% (OR1.75, 95%CI 1.49-2.05; p<0.0001). Vaginal delivery skewed parameters for severity of UI towards more severe forms. Moderate to severe UI after vaginal birth increased from 12.7% to 19.5% (OR1.67, 95%CI 1.35-2.07; p<0.0001), whereas pregnancy did not alter moderate to severe UI (10.6 versus 12.7%, OR1.25, 95% CI 0.98-1.59; p=0.067). The derived protective effect of C-section, i.e. bypassing vaginal delivery, amounted to a 30% reduction in UI (OR 0.57, 95%CI 0.49-0.67; p<0.0001) and 35-43% reduction of more severe forms of UI.
Interpretation of results
The results of this study contradict conclusions from some earlier cross-sectional epidemiological reports that have concluded that the protective effect of cesarean section is temporary, restricted to milder forms of UI, or even non-existent.
Concluding message
The results of this study indicate that the burden of urinary incontinence after childbirth, all intervening factors equal, does not subside with ageing, but more likely persists throughout life. Cesarean section is protective for the additive effects of vaginal delivery on urinary continence function after pregnancy.
Figure 1
References
  1. Haylen BT, de Ridder D, Freeman RM et al (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Int Urogynecol J 21:5–26
  2. Sandvik H, Hunskaar S, Seim A, Hermstad R, Vanvik A, Bratt H (1993) Validation of a severity index in female urinary incontinence and its implementation in an epidemiological survey. J Epidemiol Community Health 47:497-499
  3. Al-Mukhtar Othman J, Åkervall S, Milsom I, Gyhagen M. Urinary incontinence in nulliparous women aged 25-64 years: a national survey. Am J Obstet Gynecol. 2017 Feb;216(2):149.e1-149.e11
Disclosures
Funding The study was supported by a National grant (no. 11315) and grants from the Go¨ teborg Medical Society, Hjalmar Svenssons Fund, and the Healthcare Committee, Region Va¨ stra Go¨ taland. The funding sources had no role in study design, data analysis, data interpretation, or writing of the report. Clinical Trial No Subjects Human Ethics Committee Ethical approval for the study was obtained from the regional ethical review board in Gothenburg, Sweden (reference no. 381-07 and number 776-13; Nov. 18, 2013). Helsinki Yes Informed Consent Yes