DETRUSOR CONTRACTILITY IN WOMEN: COMPARISON OF EVALUATION USING BLADDER CONTRACTILITY INDEX (BCI), PROJECTED ISOVOLUMETRIC PRESSURE 1 (PIP1) AND VBN CONTRACTILITY PARAMETER (k).

Valentini F1, Marti B1, Nelson P1

Research Type

Clinical

Abstract Category

Female Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 113
E-Poster 1
Scientific Open Discussion ePoster Session 7
Wednesday 4th September 2019
13:00 - 13:05 (ePoster Station 5)
Exhibition Hall
Urodynamics Techniques Voiding Dysfunction Female Mathematical or statistical modelling Retrospective Study
1.Hôpital Rothschild
Presenter
F

Françoise Valentini

Links

Poster

Abstract

Hypothesis / aims of study
Evaluation of detrusor contractility in women remains a great challenge. Previous studies were attempts to evaluate detrusor contractility in men using a bladder contractility index (BCI) [1]. This index is calculated from detrusor pressure at maximum flow pdet.Qmax and maximum flow Qmax with the following formula: BCI = pdet.Qmax + 5*Qmax. 
Suitability of this formula has been discussed for women because it led to a great overestimation and a simple index called projected isovolumetric pressure 1, (PIP1 = pdet.Qmax + Qmax) has been proposed [2]. Recently a nomogram, based on the VBN mathematical model, has been proposed to evaluate detrusor contractility (parameter VBN k) in women from pdet.Qmax, Qmax and initial bladder volume (Vini); the curves were fitted by algebraic equations easily programmable in Excel [3].
For the first time, analysis of detrusor contractility can be proposed in a large female population.
So, the aims of this study were to compare BCI, PIP1 and k in a population of non-neurological women referred for evaluation of various lower urinary tract symptoms and to search for the influence of age, main complaint and urodynamic diagnosis.
Study design, materials and methods
Urodynamic tracings obtained during cystometry (triple lumen urethral catheter 7F) and intubated flow (IF) of non-neurological women referred for investigation of various lower urinary tract symptoms were analyzed. Post void residual volumes (PVR) were measured using a Bladder-scan. The initial bladder volume was Vini = voided volume + PVR. 
Exclusion criteria were to be unable to void and/or expelled catheter during IF, voided volume either from FF or IF <100 mL and prolapse of grade ≥ 2.
In the contrary of BCI and PIP1, k was without unit.
Results
1- Age
Looking at age sub-groups defined as “reproductive (< 45 y)”, “peri-menopause (46-65 y)” and “post-menopause (> 65y), BCI, PIP1 and k decreased with ageing, each sub-group being significantly different of the others.
2- Main complaint (table)
There was no significant difference in BCI except between MUI and Other (p= .0259) while PIP1 was significantly higher in UUI vs. Other (p= .0161) and k in UUI vs. SUI (p=.0107) and MUI (p=.0010).
3- Urodynamic diagnosis (Figure)
After urodynamic session, a urodynamic diagnosis (UD) was posed according to the ICS/IUGA recommendations. UD were bladder outlet obstruction (BOO), detrusor overactivity with impaired contractility (DHIC), detrusor overactivity (DO), detrusor underactivity (DU). Some investigations were found “normal” (N) and other related to urethral dysfunction (intrinsic sphincter deficiency (ISD) or voiding triggered by urethral relaxation (URA)).
Some surprising results: a) a low value of BCI for BOO vs. DO while PIP1 and k values were high and similar for these two UD b) a relatively high value of BCI for DHIC close to the value for BOO while PIP1 and k were low.
Interpretation of results
Evaluations of BCI and PIP1 are obtained from data (pdet.Qmax and Qmax) of intubated flow. Same data are used to compute the VBN contractility parameter k using the associated nomogram ; although computation of k uses a volume correction. 
Detrusor contractility is found decreasing with ageing whatever the indices or parameter.
PIP1 and k  give similar results for detrusor contractility. More the value of contractility is found compatible with previous results : average when urodynamic diagnosis is « normal », low for detrusor underactivity, high for detrusor overactivity and bladder outlet obstruction [3]. This consistency shows the reliability of the evaluations using VBN parameter k and PIP1 while BCI has many inconsistencies (Figure).
Concluding message
An evaluation of detrusor contractility in women from data of intubated flow is easily obtained using indices BCI and PIP1 or using the nomogram giving VBN parameter k. Comparison of results show that PIP1 and parameter k give comparable and consistent results with urodynamic diagnosis while BCI leads to inconsistencies.
Figure 1 Table: Value of tested indices vs. main complaint
Figure 2 Figure: Variations of BCI, PIP1 and VBN parameter k vs. urodynamic diagnosis
References
  1. Schäfer W. Analysis of bladder outlet function with the linearized passive urethral resistance relation, linPURR, and a disease-specific approach for grading obstruction: from complex to simple. World J Urol 1995; 13: 47–58
  2. Tan TL, Bergmann MA, Griffiths D, Resnick NM. Stop test or pressure-flow study? Measuring detrusor contractility in older females. NAU 2004; 23: 184-9
  3. Valentini FA, Marti BG, Nelson PP, Zimmern PE, Robain G. Usefulness of an algebraic fitting of nomograms allowing evaluation detrusor contractility in women. Prog Urol. 2017 ; 27(4): 261-6. doi: 10.1016/j.purol.2016.06.010.
Disclosures
Funding none Clinical Trial No Subjects Human Ethics not Req'd It involved retrospective analysis of urodynamic studies from a database. Helsinki Yes Informed Consent Yes