Hypothesis / aims of study
In the past years, minimally invasive surgical techniques for the treatment fo benign prostatic hyperplasia have been introduced. Open prostatectomy (OP) is still the most effective treatment for BPH, however it is as well the most invasive. To overcome the limitations of OP, robotic/laparoscopic simple prostatectomy has been recently inroduced. Aim of our study is to analyse outcomes and safety of open, laparoscopic and robotic simple prostatectomy.
Study design, materials and methods
A consecutive series of men with lower urinary tract symptoms and large prostates (>80cc) undergoing laparoscopic (LSP), robotic (RASP) or open simple prostatectomy (OSP) were enrolled between January and Semptember 2018 in three centers. Outcomes were evaluated considering the trifecta favourable outcome which was defined as reported in the literature as a combination of the following items: (1) no perioperative complications, (2) postoperative IPSS <8, and postoperative Qmax >15 ml/s. Complications were evaluated according to the modified Clavien classification system. Univariate and multivariate binary logistic regression was performed to identify predictors of a positive trifecta outcome. Predictive accuracy was assessed with L-ROC.
Results
Overall 159 patients were prospectively enrolled (32 Robotic, 66 Laparoscopic, 61 open). Preoperative characteristics are described in table 1. IPSS, Qmax significantly improved in all the three groups (table 1) when compared to baseline (p<0.001). The overall complication rate was 10/61 (16 %) for OSP, 6/66 (9%) for LSP and 3/32 (9%) for RSP, however most of the complications were low grade complications according to modified Claviend-dindo classification (Grade ≤2).
Interpretation of results
Overall, 51/66 (77%) of the patients presented a positive trifecta outcome after LSP, 24/32 (75%) after a RASP and 49/61 (80%) after OSP; p= 0.517. On multivariate analysis, adjusted for ASA score, only Age (OR: 0.88; CI:0.79-0.97, p=0.014), and preoperative symptoms (OR:0.86, CI:0,75-0.98, p= 0.028) were independent predictors of positive trifecta outcome. The multivariable model has a predictive accuracy of 0.84.