Exploring pelvic floor muscle activity in male lower urinary tract symptoms

Vrolijks R1, Knol-de Vries G1, Notenboom-Nas F1, Witte L2, Blanker M1

Research Type

Clinical

Abstract Category

Male Lower Urinary Tract Symptoms (LUTS) / Voiding Dysfunction

Abstract 217
Male Lower Urinary Tract Symptoms 1
Scientific Podium Short Oral Session 11
Wednesday 4th September 2019
16:45 - 16:52
Hall K
Male Pelvic Floor Questionnaire
1.Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen. The Netherlands, 2.Department of Urology, Isala Clinics Zwolle, The Netherlands
Presenter
G

Grietje E Knol-de Vries

Links

Abstract

Hypothesis / aims of study
Although male lower urinary tract symptoms (LUTS) have a multifactorial origin, the potential role of pelvic floor muscle (PFM) function has not been studied well in men. This may be due to difficulties in the assessment of PFM activity. These difficulties may be overcome using the Multiple Array Probe Leiden (MAPLe®), which is a probe with a matrix of 24 electrodes capable of anally registering EMG signals of individual pelvic muscles (1). To date, reported data in males incorporated healthy men only. We are unaware of any studies in male patients with LUTS. Therefore, the aim of the present study was to explore the association between PFM activity and symptom severity in men with LUTS.
Study design, materials and methods
We performed an observational study including adult men referred to a urology outpatient department for uncomplicated LUTS. As part of the standardized outpatient assessment, all men completed questionnaires (International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS)) before their first appointment. Patients (≥18 years of age) with an IPSS score of 8 or higher were eligible for this study. Patients with insufficient knowledge of the Dutch language, a history of prostate cancer, bladder cancer, or prostate or bladder surgery were excluded. Men who were willing to participate provided written informed consent. Directly following the urologist appointment, additional assessment of the pelvic floor muscles was performed using MAPLe®, according to the manufacturers’ protocol. This included the following tasks in supine position: 1-minute rest, five maximum voluntary contractions (MVC) held for 3 seconds and three maximal endurance contractions held for 15 seconds. 
We retrieved raw output data (for each electrode) through the MAPLe® manufacturer. These data were used to assess muscle activity, during each task, for the following PFM groups: puborectalis (PR), external anal sphincter (EAS), internal anal sphincter (IAS), pubo- and iliococcygeus (PIC) and urogenital diaphragm (UDF). So, for each PFM group three outcomes were calculated.
To explore the possible association between PFM groups, we present the outcomes of the five muscle groups for the three tasks (rest activity, MCV and endurance). Friedman’s test with a post hoc analysis Wilcoxon signed ranks test was used to assess the difference in µV between the different pelvic floor muscle groups, separately for the three tasks. 
To explore the possible association between PFM activity and symptom severity, we applied correlation coefficients between the outcomes of the PFM activity and the OABSS and IPSS scores. A Bonferroni correction for multiple testing was applied. A p-value of 0.005 or smaller was considered statistically significant.
Results
Data from 57 men (aged 67±10 years, mean IPSS score 19.2±6.2, mean OABSS score 6.1±3.2) showed that during the 1-minute rest task no significant differences were measured between the separate muscle groups (Figure 1A). Therefore, in further analyses the five muscle groups were combined for the 1-minute rest task. During the MVC task the EAS showed significantly lower muscle activity (μV) than the IAS and PR (Figure 1B). During the endurance task, the EAS had a significantly lower muscle activity (μV) than the other four muscle groups (Figure 1C). 
There were no significant associations between PFM activity and symptoms measured with IPSS and OABSS (Table 1). The highest correlation coefficient was 0.21. None of the coefficients was statistically significant (all p >0.005).
Interpretation of results
PFM rest activity did not differ between the five muscle groups. However, the EAS showed lower muscle activity than the other muscle groups during the MVC and endurance tasks. In general, muscle activity was lower for all muscle groups and all tasks when compared with the results from an earlier study in healthy subjects (1). In our study, the EAS showed the lowest muscle activity in all three tasks, while the EAS showed the highest activity in the study with healthy volunteers. We cannot explain these differences, as one might expect higher PFM activity in men with LUTS. Measurements were performed using the same protocol in both studies.
The absence of an association between PFM activity and LUTS symptom severity in our study needs further exploration. It is unclear if this is due to a true absence of such association, or due to the MAPLe® assessment, or testing situation (not during voiding).
Concluding message
This is the first study exploring PFM activity in a large group of men with LUTS. We found no association between PFM activity and LUTS severity as measured by OABSS and IPSS. Future studies should explore this in more detail, possibly looking for subgroups of patients with pelvic floor problems. Furthermore, larger studies in the general population are warranted to generate normal values of PFM activity. Of specific interest would be to monitor PFM activity during voiding.
Figure 1
Figure 2
References
  1. Voorham-van der Zalm et al. Reliability and Differentiation of Pelvic Floor Muscle Electromyography Measurements in Healthy Volunteers Using a New Device: The Multiple Array Probe Leiden (MAPLe). Neurourol Urodyn 2013;32:341–348.
Disclosures
<span class="text-strong">Funding</span> None <span class="text-strong">Clinical Trial</span> No <span class="text-strong">Subjects</span> Human <span class="text-strong">Ethics Committee</span> Medical Ethical Committee of Isala Clinics Zwolle <span class="text-strong">Helsinki</span> Yes <span class="text-strong">Informed Consent</span> Yes