Hypothesis / aims of study
The EAU guidelines on Neurogenic Bladder state that urodynamic investigations should be carried out at least every 1-2 years on neurogenic patients in order to protect the upper tracts. The results of urodynamic investigations are used to make decisions regarding safe bladder management. Our local practice is to use a lubricating gel for insertion ofurodynamic catheters which includes a local anaesthetic (lidocaine) and an anti-septic (chlorhexidine). In a small cohort of our spinal cord injured (SCI) patients there is a discrepancy between the urodynamic results including cystometric capacity (CC), leakage and maximum detrusor pressure (MDP) and the patient reported bladder volumes and leakage. We hypothesised that the active ingredients in the lubricating gel may be triggering exaggerated reflex responses in some SCI patients which contributed to the discrepancy. In some of the identified patients we have performed repeat cystometry using lubricating gel with no added ingredients.
Study design, materials and methods
The study used mixed methods; a retrospective analysis and a prospective evaluation. The clinical records of patients who underwent urodynamics in our centre were searched to identify patients who were potentially sensitive to active ingredients in lubricating gel, based on a discrepancy between urodynamic findings and reported bladder function. These patients were then prospectively followed and repeat cystometry was performed using a gel without active ingredients.
Interpretation of results
Comparison of the urodynamic results of patients who underwent urodynamics using lubricating gel with and without active ingredients showed that the urodynamics without active ingredients gave results that correlated much better with patient reported bladder function with regard to CC and a reduction in MDP.