Urinary dysfunction - Clinical diagnosis and Urodynamics, does it correlate?

THOMAS B1

Research Type

Clinical

Abstract Category

Urodynamics

Abstract 325
E-Poster 2
Scientific Open Discussion ePoster Session 18
Thursday 5th September 2019
13:15 - 13:20 (ePoster Station 4)
Exhibition Hall
Voiding Dysfunction Urgency Urinary Incontinence Mixed Urinary Incontinence
1.Leigh Infirmary, WWL NHS Trust
Presenter
B

Binu Thomas

Links

Poster

Abstract

Hypothesis / aims of study
INTRODUCTION:

The arguments for and against routine use of Urodynamic study in the assessment of lower urinary tract dysfunction and urinary incontinence has been a well-known topic of debate among the clinicians for a long time. Many clinicians still feel that routine use of this investigation is not necessary prior to treatment even when they know that, better understanding of the patho-physiology of lower urinary tract dysfunction can be gained by Urodynamic study. 

AIM: 

To assess whether the clinical diagnosis based on the symptom evaluation in the diagnosis of various types of urinary dysfunction correlates with urodynamic study findings.
Study design, materials and methods
100 consecutive patients who attended for urodynamic evaluation of urinary dysfunction  were selected for this study. 50 consecutive females and 50 consecutive males were included making a total number of 100. The patients described various  lower urinary tract symptoms including urinary incontinence. They were referred to our department mainly by their General Practitioners, Physicians or Gynaecologists. All patients were initially seen at the urology out-patient clinic and was referred for urodynamic evaluation for assessment based on the clinical diagnosis.

Methods:
All of the patients were evaluated for Urodynamic study using  Life-Tech Urovision Janus Urodynamic machine. Prior to their urodynamic evaluation  an IPSS score for men and symptoms evaluation for women were under taken by the clinician. Each patient was asked to void in to the uroflow meter initially and a flow trace is recorded and the urine sample was analysed by simple dipstix test. If the patient was found to have nitrites in their urine or leucocytes in association with symptoms suggestive of urinary tract infection, further urodynamic investigation was deferred and the urine was sent for microbiological testing. The patients were asked whether this free flow was representative of their  normal pattern of voiding and if not the procedure was repeated with full bladder. The residual urine within the bladder after micturition was checked using a portable bladder scanner and was recorded. The patient’s bladder was filled with normal saline at room temperature at various rates, usually at  50 mls per minute for the non-neuropathic patients and 10 ml per minute for the neuropathic patients. The patients were kept in the supine posture. Patients were told to inform when they experienced any sensation of filling their bladder. The patients were asked to inform when they get the first desire to void , normal desire to void, strong desire to void and urgency during the bladder filling phase and they were recorded. They were asked to cough at regular intervals and each episode was recorded to monitor good subtraction from the rectal catheter and the intravesical pressures. Any abnormal detrusor contraction , leak etc were recorded. When the patients felt that their bladder was full further coughing and straining were repeated to see if stress incontinence was present. The bladder filling was stopped when the patients felt that their bladder was full and the infused volume was recorded. Then they were asked to stand up and void  while detrusor pressure was continuously measured. The voided volume was recorded. When voiding was completed the study was terminated. Method and diagnostic criteria were according to the recommendations published in the report on standardization by the International Continence Society.

The data collected from clinical notes and urodynamic study results were analysed using MS Excel spread sheet. Mean, standard deviation (SD), range  (minimum to maximum), frequency and percentage were used to summarise the variables as required. Bar-charts, and pie-charts were used for the graphical representation of the data.
Results
Among the 100 patients, whose symptoms were analysed, it was found that   64 patients had  voiding symptoms. Out of 50 men who came for urodynamics,  39 of them had significant obstructive type voiding symptoms (78%) and 49 of them (98%) had associated storage symptoms. Of the 50  women, 25 (50%) had voiding symptoms and 40 (80%)had storage symptoms. The bladder outflow obstruction index which is otherwise called as Abrams-Griffiths number was calculated in men using the formula  BOOI = Pdet at Q max - ( 2x Q max ). When the Index value was less than 20  it was considered as no obstruction, the value between 20 to 40 was considered as equivocal and when it was above 40 it was considered as obstruction  In this study it was noted that out of 100 only 26 patients (26%) were actually obstructed.  

35 patients were found to have detrusor over activity out of 66 patients who presented with symptoms of urge incontinence. In 31 patients urge incontinence could not be demonstrated Urodynamically. But 4 patients who actually presented with urge incontinence diagnosed to have Urodynamically proven stress urinary incontinence!
 
33 patients complained of stress urinary incontinence with only 19 having Urodynamically proven stress incontinence. Among the 33 patients who gave symptoms of stress urinary incontinence, 13 had detrusor over activity(39.3%) on urodynamic evaluation. 
             
Thus the overall incidence of detrusor over activity was 38% and overall incidence of stress incontinence was 23%.
Interpretation of results
Among these 100 patients then comparison was made between the clinical diagnoses based purely on the clinical symptoms made by the referring clinician  to the final diagnoses after Urodaynamic study, it was found that only for 53 patients (53%) there was similarity between the two and for 47 patients (47%) the clinical diagnosis purely based on symptoms were not keeping in with the final diagnosis after urodynamic evaluation.

When the final outcome of the urodynamic study was compared to the initial plan made at the out patient clinic for each patient, it was found that for 34 (34%) patients the findings of urodynamics had a significant impact in their treatment as the management  plan was  subsequently changed depending upon the urodynamic diagnosis. In 54 (54%) patients the urodynamic findings confirmed the clinical diagnosis and thereby helped significantly in subjecting the patient for invasive treatment options. In rest of the small group of 12 (12%) patients, urodynamic study did not have significant influence in their management plan.
Concluding message
The present diversity in the success rates after urinary incontinence and bladder neck surgeries denotes the difficulty in arriving at an accurate diagnosis purely based on clinical symptoms.  Patients with lower urinary tract dysfunction including stress or urgency urinary incontinence should have a urodynamic evaluation since the detrusor overactivity  rate is known to be high. (38% in this study).We noted that more than half of the patients who presented with symptoms of bladder out flow obstruction did not have urodynamically proven diagnosis of obstruction but had other conditions of poor bladder emptying and urodynamic study resulted in changing the management plans. Nearly half of the patients in this study (47%) did not have correlation between the initial clinical diagnosis and plan made based purely on the clinical symptoms by the referring clinician when compared to the final diagnosis after urodynamic evaluation. In majority (88%), the outcome of  urodynamic evaluation influenced the treatment . In 34% patients the treatment plan had altered altogether after urodynamic evaluation. ‘Bladder is an unreliable witness’ , the well known statement of Blaivas JG in 1996 still holds true as the urodynamics has a major role in the assessment of lower urinary tract dysfunction prior to proceeding with any bladder neck surgeries.
References
  1. Adams E, Bradsley A, Hilton P , et al. Urinary Incontinence : The management of urinary incontinence in women. NICE clinical guideline 40 .UK: National Institute for Health and Clinical Excellence; 2006
  2. Blaivas JG. The bladder is an unreliable witness. Neurourol Urodyn 1996;15(5):443-5
  3. Chapple C. Primer: Questionnaires Versus Urodynamics in the evaluation of Lower Urinary Tract Dysfunction- One, Both or None ? Nature Clinical Practice Urology. (Medscape Published 12/13/2005)
Disclosures
Funding None Clinical Trial No Subjects None