Hypothesis / aims of study
Mixed urinary incontinence (MUI) is common disease among women with urinary incontinence. But, there is no optimized and standardized principle of treatment for MUI. Associated factors that can predict the postoperative outcomes of MUI are unclear. We tried to determine predictive clinical factors for postoperative success rate and postoperative satisfaction in female patients with equal severity for stress and urge MUI, so this study attempted to investigate the predictors affecting postoperative 2 years outcomes of equal severity for stress and urge MUI.
Study design, materials and methods
The study consisted of 90 patients who had been diagnosed with equal severity for stress and urge MUI. The exclusion criteria of patients were (1) stress predominant-MUI, (2) urge predominant-MUI, (3) neurogenic bladder.
The postoperative success rates were classified into 2 groups according to the degree of postoperative incontinence status as (1) cure group (CG, no incontinence and up to 50% improved), and (2) fail group (FG, fail). The degree of postoperative satisfaction is classified into 2 groups as (1) satisfaction group (SG, very satisfied and satisfied) and (2) dissatisfaction group (DG, equivocal and dissatisfied). All patents were performed a full examination and full urodynamic study. A analysis was performed by chi-square or T-test for categorical variables, respectively. Univariate logistic regression analysis was used to determine the risk factors affecting postoperative outcomes. Independent risk factors were calculated by multivariate logistic regression analysis. Statistically significant was set at P<0.05.
Results
Total 90 patients: (1) postoperative satisfaction as 66 (SG, 73.3%), 24 patients (DG, 26.7%) and (2) postoperative cure as 84 patients (CG, 93.3%). 6 patients (FG, 6.7%).
The average age of total patients was 55.4±1.1, body mass index (BMI) was 26.3±0.3 kg/m2 and OABSS (overactive bladder symptom score) was 11.7±5.1. Urodynamic parameters consisted of such characters as bladder capacity (337.1±12.5 mL), detrusor pressure (Pdet) (36.7±1.3 cm H2O), and maximal flow rate (Qmax) (18.8±0.8 mL/sec), residual urine (RU) was 26.1±4.6 mL, maximal urethral closing pressure (MUCP) was 29.6±1.2 cm H2O and valsalva leak point pressure (VLPP) was 72.6±2.9 cm H2O.
No significant difference between SG and DG was shown with age, Qmax, Pdet, residual urine, MUCP, BMI, Stamey grade and IPSS. The differences between SG and DG in response to VLPP (P=0.041) and OABSS (P<0.001) were confirmed.
No significant difference between CG and FG was shown with age, Qmax, Pdet, residual urine, MUCP, BMI, Stamey grade and IPSS. The differences between CG and FG in response to VLPP (P=0.011) and OABSS (P<0.001) were confirmed.
Interpretation of results
Total patients were ninety women with equal severity for stress and urge MUI. Postoperative SG were 66 patients (73.3%) and DG were 24 patients (26.7%).. Postoperative success rates included CG were 84 (93.3%) and FG were 6 (6.7%). In postoperative satisfaction, significant difference included body mass index (BMI) (P = 0.028) valsalva leak point pressure (VLPP) (P = 0.041) and overactive bladder symptom score (OABSS) (P<0.001) between SG and DG. In postoperative success rates, significant difference revealed VLPP (P=0.011) and OABSS (P<0.001) between CG and FG. In univariate logistic regression analysis, BMI (OR 0.55, CI 0.316-0.971, P=0.039), maximal bladder capacity (OR 0.972, CI 0.946-0.999, P=0.044) and OABSS (OR 0.033, CI 0.002-0.453, P=0.011) show a significant between SG and DG. VLPP (OR 1.074, CI 0.963-1.199, P=0.03) and OABSS (OR 0.17, CI 0.012-2.39, P=0.02) show a significant between CG and FG.
In multivariate analysis, OABSS (adjusted OR 0.15, CI 0.047-0.477, P = 0.001) and BMI (adjusted OR 0.86, CI 0.749-0.987, P = 0.032) were independent predictor of postoperative satisfaction and VLPP (adjusted OR 1.047, CI 1.007-1.091, P = 0.023) was only independent factor of postoperative cure. Especially, in post Hoc comparison analysis, significant difference of postoperative satisfaction revealed between intrinsic sphincter deficiency (ISD) and anatomical incontinence (AI) in VLPP (P = 0.008) and between mild and severe symptom in OABSS (P = 0.002). Significant difference of postoperative cure revealed between ISD and AI in VLPP (P = 0.001).