URETHRAL SUSPENSION DURING OPEN RETROPUBIC RADICAL PROSTATECTOMY: A NOVEL METHOD TO IMPROVE EARLY POSTOPERATIVE RECOVERY OF URINARY CONTINENCE

Guercio S1, Ambu A1, Russo M1, Carchedi M1, Battaglia A1, Bellina M1

Research Type

Clinical

Abstract Category

Prostate Clinical / Surgical

Video coming soon!

Abstract 496
Urethra & Prostate
Scientific Podium Short Oral Session 26
Friday 6th September 2019
09:30 - 09:37
Hall G3
Incontinence Male Surgery
1.Department of Urology, Ospedale degli infermi di Rivoli, Turin
Presenter
A

Alessandra Ambu

Links

Abstract

Hypothesis / aims of study
Postoperative urinary incontinence after radical prostatectomy (RP) may greatly affect patients’ quality of life and may require a long time and further treatments to be addressed (1). We show our results with a novel technique for urethral suspension during RP, which is a modification of the technique originally described by JW Thuroff et al. (2); this latter considered the use of a single sling, harvested from the rectus muscle fascia, while we created one fascial limb on each side of the linea alba, then suturing both limbs to the vesico-urethral anastomosis, in order to suspend it and to avoid its downward dislocation (Fascial Anastomosis Suspension Technique: FAST).
Study design, materials and methods
A prospective, randomized, single-blind study among 40 consecutive patients  with localized prostate cancer (cT1-2 N0M0) undergoin to open Radical Prostatectomy at our institution, with nerve- bladder neck sparing technique,  from June 2017 to October 2017: our standard technique for the anastomosis includes an interrupted suture with 3 stitches on both sides (towards 11, 9, 7 on the left, and toward 1, 3, 5 on the right), and a running suture on the posterior urethral plate (GROUP 1). For the modified technique (FAST), once the anastomosis is sutured, 2 limbs of rectus muscle fascia on both sides of the linea alba are prepared, each 8 cm long and 1 cm wide, with a distal attachment; the free extremity is brought to the anastomosis and sutured to the stitch towards 7 on the left and to the stitch towards 5 on the right, under a mild perineal pressure to enhance the urethral suspension (GROUP 2). All the radical prostatectomy were performed by the same expert urologist (BM).
 In 20 patients (GROUP 1) the standard vesico-urethral anastomosis was performed without additional procedures, while in 20 patients (GROUP 2) a suspension of the anastomosis was added to the standard vesico-urethral anastomosis. 
We compared demographic data and preoperative and postoperative functional and oncological results or the two GROUPS.The primary endpoint was early continence; the secondary endpoint were perioperative and postoperative complications.
Continence results were evaluated in terms of number of pads per day and according to the International Consultation on Incontinence Questionnaire (ICIQ) score at 24 and 48 h and at 4 weeks postoperatively. Continence was defined as the need of 0-1 pad per day.
Results
There were no significant differences between the two GROUPS in terms of demographic and clinical data.
Continence rate (CR) for GROUP 1 and GROUP  2 was 15% vs. 40% at 24 h 20% vs. 50% at 48 h, and 30% vs. 70% at 4 weeks, respectively (p< 0.05). No urinary obstructive complications or perineal pain were recorded in patients who received a modified anastomosis suspension technique. 
There were two postoperative complications (1 in each GROUP): one haematomas and one lymphocele (p> 0.05)
Interpretation of results
Although on a small series of patients, our results show better early continence results for the patients who received a urethral suspension according to our technique, compared to patients who underwent RP according to a standard anastomosis technique without vesico-urethral anastomosis suspension. The mechanism on which early recovery of urinary continece following urethral suspension may be related, is basically unknown. Our hypothesis is that vesico-urethral anastomosis suspension created with 2 limbs of rectus muscle fascia may provide an additional support to the urethral striated sphincter, and a further stabilisation of posterior urethra within the pelvic diaphragm, while avoiding the potential obstructive complications on urinary flow related to sling compression.
Concluding message
We showed that postprostatectomy incontinence can be improved using a new technique for vesicourethral anastomosis during open radical prostatectomy . Anastomosis suspension technique is a sample and feasible procedure in open Radical Prostatectomy and can improve the early return of continence after radical prostatectomy. The FAST could significantly improve the quality of life of patients after prostatectomy.
References
  1. Nelson JB: The ongoing challenge of urinary incontinence after radical prostatectomy. J Urol 198: 1223-1225, 2017.
  2. Fokaefs E. D., Lampel A., Hohenfellner M., Lazica M., Thuroff JW: Experimental evaluation of free versus pedicled fascial flaps for sling surgery of urinary stress incontinence. J Urol, 157: 1039-1043, 1997
Disclosures
Funding no Clinical Trial No Subjects Human Ethics not Req'd present only a review of a standardised technique Helsinki Yes Informed Consent Yes