Dynamic features pelvic floor muscle contraction differ between men with and without incontinence after prostatectomy and men with no history of prostate cancer

Hodges P1, Stafford R1, Coughlin G1

Research Type

Clinical

Abstract Category

Male Stress Urinary Incontinence (Post Prostatectomy Incontinence)

Abstract 544
Pelvic Floor Muscle Assessment and Treatment
Scientific Podium Short Oral Session 30
Friday 6th September 2019
12:00 - 12:07
Hall G1
Male Physiotherapy Incontinence Imaging Pelvic Floor
1.The University of Queensland
Presenter
P

Paul Hodges

Links

Abstract

Hypothesis / aims of study
Incontinence is a major issue after radical prostatectomy; affecting up to 60% of men. Although many men recover within 12 months, some continue to have long terms problems with a major impact on their quality of life. Radical prostatectomy removes smooth muscle of the internal sphincter, which places greater demand on the striated muscles of the pelvic floor to recover continence. “Sphincter insufficiency” is considered to be a major determinant of incontinence after prostatectomy, yet this concept oversimplifies the complex interaction of activity of multiple striated muscles that is required to maintain continence and other factors that challenge continence such as elevated intra-abdominal pressure. A major limitation has been that simultaneous measurement of the multiple muscles that can contribute to continence has been difficult, invasive and unlikely to be viable in clinical practice. Recent work has validated measurement of dynamic motion of pelvic structures using transperineal ultrasound imaging as a measure of activation of the striated urethral sphincter (SUS), puborectalis (PR) and bulbocavernosus (BC) muscles [1]. Initial work has highlighted some differences in men with and without incontinence after prostatectomy [2].  

This study aimed to compare dynamic (activation of SUS, PR and BC muscles) and anatomical (urethral length) features related to urinary continence control between men with and without incontinence after prostatectomy, and between these men and an age-matched group of men with no history of prostate disease or incontinence. The objective was to test the hypotheses that pelvic floor muscle function would be a determinant of why some men recover continence and others do not, and that recovery of continence requires augmentation of muscle function beyond that required to maintain continence in men without prostate disease/surgery. The second aim was to identify the amplitudes of pelvic floor muscle displacement that best discriminate between men with and without incontinence after radical prostatectomy.
Study design, materials and methods
The study included men with incontinence post-prostatectomy (PPI; n=20), continent men post-prostatectomy (PPC; n=23) and a control group with no history of prostate disease or incontinence (CC; n=20). In supported sitting, an ultrasound transducer (Aixplorer, SuperSonic Imagine, France) was placed on the perineum to visualise the urethra, bulb of penis, ano-rectal junction and bladder in a single view. Using this transperineal ultrasound imaging technique we recorded motion associated with contraction of the SUS, PR and BC muscles during maximal voluntary contraction (MVC), sub-maximal voluntary efforts, evoked coughing (inhalation of titrated dose of nebulised Capsaicin) and while performing a bearing down manouevre. Data were stored in video format and frames were exported for analysis with Matlab (The Mathworks, USA). Anatomical landmarks were identified and displacements between rest and contraction were measured for MVC, sub-maximal and bearing down tasks. For analysis of coughing, measures were made at the point of maximum displacement prior to, then after expulsion. Measures were compared between groups using Analysis of Variance and receiver operating characteristics (ROC) were calculated to determine the threshold displacements of pelvic structures that best differentiated PPI and PPC.
Results
PPC demonstrated greater SUS, PR and BC displacement than PPI during MVC (All: P<0.01). During cough, PPC had less bladder neck descent (less PR lengthening, which reflects the balance between intra-abdominal pressure and PR muscle activation), and greater BC shortening (P=0.003) than both PPI and CC. PPC also achieved greater SUS displacement (P=0.025) than PPI during cough. The best discrimination between PPI and PPC was achieved when men exceeded threshold displacement for both SUS (≥4.1mm) and PR (≥2.4mm) during MVC. Urethral length was not different between PPC and PPI.
Interpretation of results
Men who were continent after radical prostatectomy achieved greater shortening of the SUS, PR and BC muscles than incontinent men during voluntary contractions. Notably, during an evoked cough, men who were continent after radical prostatectomy were able to maintain better bladder support (less PR lengthening) and greater compression of the distal urethra (BC displacement) than was achieved by the control participants with no history of prostate cancer or incontinence. The capacity to shorten the SUS ≥4.1mm and the PR ≥2.4mm best distinguished between PPI and PPC.
Concluding message
These data have identified features of activation of striated muscles of the pelvic floor that could explain a contribution to the successful recovery of continence after radical prostatectomy. Notably, for some tasks it appears that muscle function needs to exceed “normal” values for successful continence control. The threshold muscle function that differentiated groups might be a useful clinical target for conservative treatment programs.
References
  1. Stafford RE, Coughlin G, Lutton NJ, Hodges PW. Validity of Estimation of Pelvic Floor Muscle Activity from Transperineal Ultrasound Imaging in Men. PLoS One 2015; 10(12):e0144342.
  2. Stafford RE, van den Hoorn W, Coughlin G, Hodges PW. Postprostatectomy incontinence is related to pelvic floor displacements observed with trans-perineal ultrasound imaging. Neurourol Urodyn 2018; 37(2):658-665.
Disclosures
Funding National Health and Medical Research Council Clinical Trial No Subjects Human Ethics Committee University of Queensland Human Research Ethics Committee Helsinki Yes Informed Consent Yes