Hypothesis / aims of study
Pelvic floor disorders (PFDs) either anatomical (pelvic organs prolapse) or
functional (urinary incontinence and stool incontinenc) negatively affect quality of life in the
general population. In fact every second female patient in postmenopausal age suffer
from urinary incontinence or pelvic organ prolapse, whereas 6% to 19% of this population
may demand surgery in the future. (1) The prevalence of PFD in various gynecologic
cancer survivors has not been systematically studied. This study aimed to determine the
prevalence of PFDs in women after various types of oncological therapy. We hypothesized
that the prevalence of PFDs in the gynecological cancer survivors would be higher than in
the general female population. It is obvious that surgery itself, but also additional
oncological treatment (radiation, radiochemotherapy) can negatively affect not only
genitourinary system, but also quality of life. (2,3)
Therefore the aim of this study was to determine the impact of treatment used
among female oncological patients before and 6 months after therapy due to various gynecological malignancies.
Study design, materials and methods
The study was conducted on the group of 160 patients age between 28 to 87 years. All the patients were diagnosed with gynecological malignancy and underwent surgery in the years 2015-2016.
All the patients signed up the consent agreement form, filled up the questionnaires and self-assessed general wellbeing using the 7-points Likert's Scale.
A standarized and validated forms of: SF-36 v.2 Questionnaire (assessing general quality of life), King's Health Questionnaire (assessing general quality of life with concommitant LUTS) and short forms of UDI-6 (assessing prevalence of urinary incontinence) and II-Q7 (assessing the impact of urinary incontinenceon everyday functioning) were used in the study.
Statistical analyses were performed with Statistica package version 12.0 (StatSoft Inc.,Tulsa, OK, USA). A p value <0.05 was considered statistically significant.
Interpretation of results
The study resulted in certain conclusions considering: more than 50% of female oncological patients suffer from pelvic floor disorders at the moment of oncological disease diagnosis. Oncological treatment results in the deterioration in pelvic floor disorders. Type of surgery results in deterioration of the urogynecological symptoms and quality of life in oncological patients group. Combination of surgical and additional oncological therapy results in the higher prevalence of urogynecological symptoms. Among oncological therapies: pelvic radiation and radiochemotherapy seem to mostly negatively affect female pelvic floor.