RESULTS OF THE CORRECTION OF URINARY INCONTINENCE AFTER RADIOTHERAPY AFTER PROSTATECTOMY AND ITS RELATIONSHIP WITH THE DEVICE USED

Padilla-Fernández B1, Linares-Mesa N2, Hernandez Sanchez T3, Alvarez-Ossorio Rodal A4, Marquez-Sanchez M5, Marquez-Sanchez G4, Valverde-Martinez S6, Lorenzo-Gomez A7, García-Cenador M4, Castro-Diaz D1, Lorenzo-Gomez; Maria Fernanda L8

Research Type

Clinical

Abstract Category

Male Stress Urinary Incontinence (Post Prostatectomy Incontinence)

Abstract 264
ePoster 4
Scientific Open Discussion Session 20
On-Demand
Male Incontinence Retrospective Study
1. Urology Section of Departament of Surgery of University of Laguna, Tenerife. Spain., 2. Departament of Surgery of University of Salamanca. Spain.Radiotherapy Departament of University Hospital of Juan Ramón Jimenez. Huelva. Spain., 3. Urology Departament University Hospital of Salamanca. Spain., 4. Departament of Surgery of University of Salamanca. Spain., 5. Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain., 6. Urology Departament of University Hospital of Avila. Spain.Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain., 7. Nursing of Hospital Complex of Zamora. Spain., 8. Departament of Surgery of University of Salamanca. Spain. Urology Departament University Hospital of Salamanca. Spain. Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain.
Presenter
L

Lorenzo-Gomez; Maria Fernanda Lorenzo-Gomez; Maria Fernanda

Links

Abstract

Hypothesis / aims of study
INTRODUCTION:
Regardless of the technique used, the most frequent cause of male stress urinary incontinence (MUI) continues to be radical prostatectomy for prostate adenocarcinoma. The pathophysiological mechanism of MUI lies in the primary injury to the periurethral sphincter and/or in the destruction of the supporting structures.
There is a high percentage of patients with continence problems, being lower those with moderate/severe incontinence, but continuing to be a high percentage (1).
Genitourinary toxicity after radiotherapy consists in acute symptoms, generally self-limiting, irritative symptoms predominate, including increased urinary frequency, dysuria and/or urgency due to cystitis, urethritis or both (2), sometimes incontinence appears accompanied by urinary urgency in the context of an overactive bladder. The risk of urinary incontinence after TEN can generally be considered very low with rates of 0-10% depending on the definition used (3).

OBJECTIVES: To know the results of the treatment of male urinary incontinence (MUI) in patients who have received radiotherapy (RT) after radical prostatectomy (RP) for the treatment of prostate cancer and the factors that influence them.
Study design, materials and methods
A retrospective multicentre study of 226 patients treated with RP plus RT who are implanted with a device to correct the MUI. Groups: GA (n = 137): successful result = total continence. GB (n = 89): failure result = incontinence. Subgroups: "s" ("success": a year continues with urinary continence or they get it; Subgroup "f" ("failure"): a year they continue with MUI or recurrence. Variables: Age, BMI, PSA, TNM, Gleason, prostate volume, follow up time, secondary diagnoses (DDSS), history, device: Transobturator suburethral tape (TOT), intraurethral adjustable suburethral tape (ATOMS® or PHORBAS®), or suprapubic level adjustable suburethral tape (REMEEX®), MUI grading Descriptive statistics, ANOVA analysis, Student's t-test, Fisher's exact test, multivariate analysis, p <0.05 was considered significant.
Results
Media age 69 y.o. (59-82), younger in GA. The time between diagnosis of MUI and corrective surgery: media 7 years, in GA less than GB (p = 0.0006); In GA, GAs was lower than GAf; GAs lower than GBe. Medical DDSS in GA greater comorbidity in GAf versus GAs. In GA more surgical history in GAf versus GAs. In GB more arterial hypertension, diabetes mellitus, anxiety and depression in GBf compared to GBs. History of prostate adenomectomy plus in GAf (83%) versus GBf (5%). There are no differences between TOT and REMEEX® in GA. Adjustable suburethral tapes (ATOMS® or PHORBAS®): more cases in GAf (table1).
Interpretation of results
Some patients with ATOMS were rescued in second time. If REMEEX® device fails to start, it is better to switch to artificial urinary sphincter.
Concluding message
MUI treatment after PR + RT with suburethral anti-incontinence devices have an initial success rate of 60.66% and in the second time, they reach 82.74%. Younger patients have a better prognosis. BMI, PSA or prostate volume do not influence the outcome, unlike Gleason, longer MUI evolution time, pre-PR LUTS and more DDSS, which are associated with failure.
Figure 1 History of prostate adenomectomy
References
  1. Graham J, Kirkbride P, Cann K, Hasler E, Prettyjohns M. Prostate cancer: summary of updated NICE guidance. Bmj. 2014;348:f7524.
  2. Dearnaley DP, Hall E, Lawrence D, Huddart RA, Eeles R, Nutting CM, et al. Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects. British journal of cancer. 2005;92(3):488-98.
  3. Beckendorf V, Guerif S, Le Prise E, Cosset JM, Lefloch O, Chauvet B, et al. The GETUG 70 Gy vs. 80 Gy randomized trial for localized prostate cancer: feasibility and acute toxicity. International journal of radiation oncology, biology, physics. 2004;60(4):1056-65.
Disclosures
Funding No Clinical Trial No Subjects Human Ethics Committee University Hospital of Avila, Spain Helsinki Yes Informed Consent No
03/05/2024 04:07:40