Study design, materials and methods
We performed a retrospective study focused on the evolution of post-surgical treatment of OAB in patients with an AUS implant. For analysis purpose we used data from our experience with a similar series of patients with OAB after prostate surgery (non-neurogenic) and no AUS. In the AUS group, urodynamic studies were available before and twice after the implant. The OABq questionnaire was used. After the diagnosis of de novo OAB, treatment was started as per our standard of care, with antimuscarinics alone or in combination with β3 agonists. T-test analysis was performed for comparison of QABq and urodynamic parameters in both series.
A total of 12 patients with OAB post AUS implantation were included, aged 49 to 88 years old. In all cases, an overactive detrusor was confirmed by urodynamics. We could not identify any predictive factor for de novo OAB in the pre-implant urodynamic evaluation. After treatment, in the AUS group, we noticed no statistical significant variation of the OABq and urodynamic parameter, while in the control group all parameters were improved.
Interpretation of results
Post prostatectomy urinary incontinence in the male patient is one of the most bothersome late complications of this surgery. Our experience shows that severe incontinence might develop regardless of the initial indication for surgery, e.g. prostate cancer or BOO. The AUS remains the ultimate treatment in this case, even if some significant drawbacks still persist. Post AUS complications include this particular and redutable type of OAB syndrome, which has suboptimal response to treatment. Unfortunately, even if the AUS has been around for almost half a century, the experience with it remains limited and there is an almost desperate need for large studies of metanalyses in order to better understand its long term behavior.