Results of the correction of post-prostatectomy urinary inconti-nence in men with previous radiation therapy and its relationship with the device used

Padilla Fernandez, Barbara-1 P1, Linares Mesa, Nuria Azahara-2,3 L2, Rocha de Lossada, Alberto-4 R3, García-Garcia, Miguel-Angel-4 G3, Alvarez-Ossorio Rodal, Andrea-2 A4, Márquez Sanchez, Magaly-5 M5, Marquez Sanchez, Gerardo-2 M4, Flores-Fraile, Maria-2 F4, Valverde Martinez, Sebastian-5.6 V6, Lorenzo-Gomez, Anabel-7 L7, García Cenador, María Begoña -2 G4, Lorenzo Gomez; Maria Fernanda-2,4,5 L8

Research Type

Clinical

Abstract Category

Male Stress Urinary Incontinence (Post Prostatectomy Incontinence)

Abstract 310
On Demand Male Stress Urinary Incontinence (Post Prostatectomy Incontinence)
Scientific Open Discussion Session 23
On-Demand
Male Incontinence Physiotherapy Retrospective Study
1. 1-Urology Section of Departament of Surgery of University of Laguna, Tenerife. Spain., 2. 2.-Departament of Surgery of University of Salamanca. Spain. 3.-Radiotherapy Departament of University Hospital of Juan Ramón Jimenez. Huelva. Spain., 3. 4.-Urology Departament University Hospital of Salamanca. Spain., 4. 2.-Departament of Surgery of University of Salamanca. Spain., 5. 5.- Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain., 6. 5.- Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain. 6.-Urology Departament of University Hospital of Avila. Spain., 7. 7.-Nursing of Hospital Complex of Zamora. Spain., 8. 2.-Departament of Surgery of University of Salamanca. Spain.4.-Urology Departament University Hospital of Salamanca. Spain. 5.- Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain.
Presenter
L

Lorenzo Gomez; Maria Fernanda Lorenzo Gomez; Maria Fernanda-2,4,5

Links

Abstract

Hypothesis / aims of study
To know the results of the treatment of post-prostatectomy urinary incontinence (PPUI) in patients who have received radiotherapy (RT) after radical prostatectomy (RP) for the treatment of prostate cancer and the factors that influence them.
Study design, materials and methods
Retrospective multicentre study of 226 patients treated with RP plus RT who are implanted with a device to correct the PPUI. 
Groups: 
-	GA (n = 137): successful result = total continence. 
-	GB (n = 89): failure result = incontinence. 
Subgroups: 
-	"s" ("success"): one year after surgery, patients remain continent (GAs) or they regain it (GBs); 
-	"f" ("failure"): one year after surgery, they continue with PPUI (GBf) or the incontinence recurs (GAf). 
Variables: Age, BMI, PSA, TNM, Gleason, prostate volume, follow up time, secondary diagnoses (DDSS), history, device: Transobturator suburethral tape (TOT), infraurethral-adjustable suburethral tape (ATOMS® or PHORBAS®), or suprapubic-adjustable suburethral tape (REMEEX®), PPUI grading. 
Descriptive statistics, ANOVA analysis, Student's t test, Fisher's exact test, multivariate analysis, p <0.05 was considered significant.
Results
Mean age was 69 years old (range 59-82), younger in GA. Time between diagnosis of PPUI and corrective surgery: average 7 years, lower in GA than in GB (p = 0.0006), and also lower in GAs than in GAf and in GBs. 
Regarding the medical background of the patients, comorbidities were more common in GAf than in GAs, as well as the surgical history. In GB, more arterial hypertension, diabetes mellitus, anxiety, and depression could be found in GBf than in GBs. History of prostate adenomectomy was more frequent in GAf (83%) than in GBf (5%). 
There are no differences in continence rate between TOT and REMEEX® in GA. Adjustable suburethral tapes (ATOMS® or PHORBAS®): more cases in GAf (figure 1). Some patients with ATOMS® were rescued in second time. If REMEEX® device fails immediately after the surgical intervention, it is better to switch to an artificial urinary sphincter. 
In the multiple regression, we found that age (coefficient 0.107, p= 0.0006), PSA (coefficient 0.070, p= 0.0013), Gleason (coefficient 0.941, p= 0.01017), PPUI evolution time (coefficient 0.174, p= 0.0003), pre-PR LUTS (coefficient 1.014, p=0.045), and more DDSS (coefficient 4.626, p=0.0016) had a direct association with the probability of surgical failure; in contrast, prostate volume (coefficient -0.012, p= 0.025) showed a negative correlation. No influence could be proven for BMI (coefficient -0.038, p= 0.057).
Interpretation of results
Patient’s age and the time between the diagnosis and the anti-incontinence surgery seem to have an influence in the success of the surgery itself. Also, the general health status of the patient (reflected in the comorbidities) influences the results of the anti-incontinence surgery. Previous LUTS don’t need to be in accordance with prostate volume, which can explain the different correlation signs in the multivariate analysis.
Concluding message
PPUI treatment after PR + RT with suburethral anti-incontinence devices have an initial success rate of 60.66% and in the second time they reach 82.74%. Younger patients have a better prognosis. BMI do not influence the outcome, unlike high PSA, prostate vol-ume, Gleason, longer PPUI evolution time, pre-PR LUTS and more DDSS, which are associated with failure.
Figure 1
Disclosures
Funding Multidisciplinary Renal Research Group of the Institute for Biomedical Research of Salamanca (IBSAL). Spain. Clinical Trial No Subjects Human Ethics Committee Ethics Committee for Drug Research (CEIm) of the Ávila Health Area, Ávila, Spain Helsinki Yes Informed Consent Yes
15/05/2024 11:41:45