Introduction: Urinary tract infections are one of the most frequent pathologies in kidney transplant patients. Their development and their treatment can compromise the function of the graft.
1.-Determine variables related to the prevention of deterioration of graft function
or what factors lead to said deterioration, in kidney transplantation in general. 2.-Identify what is related to
worse graft function in patients receiving kidney from a living donor. 3.-Find out the factors that
are related to impaired renal function in cadaveric donors in the period before and after the
Implementation of a living kidney donor program. 4.-Establish the changes in the findings of the
follow-up of the cadaver graft, the tendency to the type of pre-transplant dialysis used or the results of the
cadaver graft rejection after implantation the living donor program regarding the findings
prior to the implementation of said program.

Material and method: Retrospective observational multicenter study with a sample of 1,300 transplant patients: TV: living-donor kidney transplant patients (n=150), TCpre11: deceased-donor kidney transplant patients in the period prior to the implementation of the living-donor program. (n=650) and TCpost11: donor kidney transplant patients’ cadaver in the period prior to the implementation of the living donor program (n=500).

Results: The mean of positive urine cultures was 3.04. The mean pre-transplant UTI was 17.7% (231). For TV 12% (n=18), TCpre11 25.69%(n=167), TCpost11 9.2(n=46). Multivariate analysis: correlation between treatment with manosar and renal function (-0.673), the lower the treatment with manosar, the greater the presence of alterations in renal function (p= 0.001).
Correlation between positive urine culture and renal function (0.050), the greater the positive urine culture, the greater the presence of alterations in renal function (p=0.0001). Correlation between the use of antibiotic prophylaxis for the treatment of pre-transplant urinary tract infections and renal function (1,189), the greater the use of antibiotic prophylaxis, the greater the presence of alterations in renal function (p=0.0002).
Correlation between the use of antibiotics on demand for the treatment of urinary tract infections pre-transplant and renal function (0.890), the greater the use of antibiotics on demand, the greater the presence of alterations in renal function (p=0.0001).

The prevention of recurrent urinary tract infections influences the evolution of renal graft function.

The presence of positive urine cultures, the need to use antibiotic therapy as a prophylactic strategy for recurrent urinary tract infections, or the use of antibiotics on demand are associated with a greater deterioration in graft function. Less use of repeat urinary tract infection prevention protocols is associated with more deterioration of graft function.