Outpatient treatment and quality of life of patients with interstitial cystitis with Hunner's lesion: a cross-sectional cohort study.

Karasev A1, Kasyan G1, Pushkar D1, Stroganov R1, Plekhanova O1

Research Type

Clinical

Abstract Category

Pelvic Pain Syndromes

Abstract 109
Urology 4 - Bladder Pain and Infections
Scientific Podium Short Oral Session 10
Thursday 18th September 2025
16:00 - 16:07
Parallel Hall 2
Quality of Life (QoL) Painful Bladder Syndrome/Interstitial Cystitis (IC) Pain, Pelvic/Perineal
1. Botkin Hospital, Moscow, Russian Federation
Presenter
Links

Abstract

Hypothesis / aims of study
Painful Bladder Syndrome/Interstitial Cystitis (BPS/IC) is a disease that significantly affects the quality of life’s patients. According to the endoscopic picture, BPS with Hunner's lesion (Hunner-type IC) and BPS not Hunner's lesion (non-Hunner-type IC) are distinguished. Both phenotypes are characterized by similar clinical manifestations but have several differences.
Current approaches to the diagnosis and therapy of IC somehow improve the patient's quality of life, but do not provide complete control of symptoms at the stage of outpatient treatment.
The purpose of our study is to evaluate the treat effectiveness of treatment and quality of patient’s life with Hunner-type IC during outpatient treatment.
Study design, materials and methods
The results of a cross-sectional cohort study assessing outpatient treatment and quality of patient’s live with a confirmed diagnosis of BPS with Hunner's lesion are presented. The respondents were asked 15 questions both online and offline. The medical chart of patients diagnosed with interstitial cystitis who received surgical treatment in the urology clinic city hospital named after S.I.Spasokukotsky were analysed. Among 90 patients, 76 met the inclusion criteria. Consent to participate in the survey was confirmed by 69 patients. The most important inclusion criteria were the absence of surgical treatment in the last three months and previously confirmed Hunner’s lesions by endoscopic technique.
Results
69 patients participated in the survey, including 1 man and 68 women. The average age of the patients was 60 years. 
Despite the absence of common tactics to maintain the interictal period, the average score of patients in this period, according to the visual analog scale for pain (VAS), was 5,7. The 35 outpatients’ treatment patients who did not seek surgical care had an average score of 4.6. A higher VAS was observed in 34 patients admitted for surgical treatment of 6,8 points.
Urine culture was noted in 63% of respondents. Relief of the symptoms against the background of taking antibiotics was noted in 59% of respondents. 
For 65% of respondents, pain is constant throughout the day. The presence of pain in other parts of pelvic area, outside the bladder, such as urethra and perineum, rarely in the groin area, was noted by 83% of respondents. 
Only 42% of patients diagnosed with interstitial cystitis continue to remain sexually active. However, 55% of sexually active patients feel pain or discomfort during sexual intercourse.
For treatment, most patients use oral Pentosan Polysulfate, amitriptyline and nitrofuran antibiotics. 
The average time from onset symptom to diagnosis was about 5 years.
Interpretation of results
Lower urinary tract infection is a criterion for ruling out the diagnosis of interstitial cystitis but more than 63% of patients have a positive urine culture. LUTS should be considered as a concomitant disease requiring treatment.
Concluding message
Current approaches to the treatment of interstitial cystitis do not provide complete control of the symptoms, which indicates the importance of improving the definition, diagnosis, and treatment methods.
Disclosures
Funding no Clinical Trial Yes Public Registry No RCT No Subjects Human Ethics Committee Ethics Committee of the FEDERAL STATE BUDGETARY EDUCATIONAL INSTITUTION OF HIGHER EDUCATION "RUSSIAN UNIVERSITY OF MEDICINE" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION Helsinki Yes Informed Consent Yes
12/07/2025 11:01:33