Study design, materials and methods
This is a single centre prospective observational cohort study. The study population included 50 consecutive male patients, with BPH with BOO undergoing TURP. Clearance was obtained from the Institutional Ethics committee for performing the study.
Standard routine care practices were followed including Patient proforma, IPSS QoL score, Uroflowmetry/PVR, USG KUB and UDS for all patients with chronic retention. After routine workup patients were subjected to TURP and post operative outcomes (IPSS QoL, Uroflowmetry/PVR, CIC requirement) was followed up at 3 months. Comparison between pre operative and post operative IPSS and Uroflowmetry findings in patients with chronic retention between high pressure and low pressure UDS tracings were done to assess if there is any significant improvement in IPSS- QoL, flow rates and post void residual volumes..
Results
In our study, The mean age of sample population is 70.28 ± 7.43. Of the 50 consecutive male patients attending our OPD who were included in the study, 21 of them had urodynamically low pressure retention while 29 of them had high pressure retention
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The pre operative flow parameters were measured and the median PVR in the low pressure group was 415 ml and high pressure group was 390ml. The preoperative median Qmax was 6.50 in the high pressure group and median Qmax in the low pressure group was 4.20, the difference between 2 groups were statistically significant (p=0.045).
The preoperative IPSS median score for the whole cohort was 24(IQR 21-27) and QoL was 5(IQR 4-6) .. The improvements in post operative IPSS and QoL scores were statistically significant (p<0.001) for the complete cohort with median IPSS score of 8.5(IQR 6-10.25) and QoL 2(1-2.2).
The results were similar on analyzing pre and post operative IPSS and QoL within the low pressure and high pressure chronic retention subgroups.
Median post operative IPSS was lower in the high pressure chronic retention group , 7.5(IQR6-10) compared to 9.5(IQR 6.5-12) , the difference was in favour of the high pressure group but was not statistically significant. There was also no statistical difference between QoL scores of the two groups.
The post operative median PVR of high pressure group was 45 (20-100) and low pressure group was 80 (40-120) which were a statistically significant improvement compared to pre operative values.
Interpretation of results
Our study did not demonstrate a significant predictive capability for preoperative urodynamics to post operative surgical outcomes.