Comorbidities of diabetes, hypertension, and cardiovascular disease and their contribution to erectile dysfunction severity in a Lebanese sample

Ghantous I1, Tlais M1, Kassem H1, Kary G1, Dib A1, Maroun G1, El Khatib A1, Ghantous G1

Research Type

Clinical

Abstract Category

Male Sexual Dysfunction

Abstract 492
Open Discussion ePosters
Scientific Open Discussion Session 104
Friday 19th September 2025
10:55 - 11:00 (ePoster Station 1)
Exhibition
Sexual Dysfunction Quality of Life (QoL) Male Outcomes Research Methods Mathematical or statistical modelling
1. Saint George University of Beirut
Presenter
Links

Abstract

Hypothesis / aims of study
Erectile dysfunction (ED) is a common condition that affects men’s quality of life. Thus, a study was undertaken to highlight the comorbid associations of ED among the Lebanese population. Considering the high prevalence of smoking in Lebanon, dietary changes, and metabolic diseases, it is important to evaluate the role of these factors in ED. Thus our study analyzes how diabetes mellitus (DM), hypertension (HTN), and cardiovascular disease (CVD) correlate with the severity of ED.
Study design, materials and methods
This cross-sectional study assessed 150 Lebanese males diagnosed with DM, HTN, and/or CVD. The International Index of Erectile Function (IIEF-5) and comorbidity data were extracted from medical records provided by urologists and used to classify ED severity. Chi-square tests and multivariate logistic regression were performed to identify predictors of severe ED.
Results
The mean age was 62.6 years, and the mean BMI was 28.3. Among participants, 40.7% had moderate ED, 31.3% had mild ED, 16.7% had severe ED, and 10% had normal erectile function. Hypertension was present in 83 patients, with 85.5% experiencing moderate to severe ED (χ² = 36.1, p < 0.001). Diabetes mellitus was the strongest predictor, with 75.9% of diabetic patients having severe ED (χ² = 42.1, p < 0.001). Cardiovascular disease had a weaker association (χ² = 7.6, p = 0.054).
Interpretation of results
The findings indicate that both diabetes and cardiovascular disease significantly contribute to the severity of erectile dysfunction, with diabetes being the most influential factor. These associations point to a strong vascular and metabolic component in ED pathophysiology and emphasize the need to address these comorbidities as part of comprehensive ED management.
Concluding message
Diabetes and hypertension are two important causes for severity of ED in Lebanese men. Although cardiovascular disease was not statistically significant, it should be further studied. Due to metabolic disorders common in Lebanon, using a multidisciplinary management approach can help alleviate the severity of ED.
References
  1. Selvin, E., Burnett, A. L., & Platz, E. A. (2007). Prevalence and risk factors for erectile dysfunction in the US. The American Journal of Medicine, 120(2), 151-157. https://doi.org/10.1016/j.amjmed.2006.02.014
  2. Shaeer, O., & Shaeer, K. (2011). The Global Online Sexuality Survey (GOSS): Erectile dysfunction among Arabic-speaking Internet users in the Middle East. The Journal of Sexual Medicine, 8(7), 2152–2163. https://doi.org/10.1111/j.1743-6109.2011.02297.x
  3. Li, H., Gao, T., & Wang, R. (2016). The role of the sexual partner in managing erectile dysfunction. Nature Reviews Urology, 13(1), 9–16. https://doi.org/10.1038/nrurol.2015.315
Disclosures
Funding Self-funded Clinical Trial No Subjects Human Ethics not Req'd This study is a secondary analysis of previously collected clinical and questionnaire data, allowing for the evaluation of comorbidity impact on erectile dysfunction severity without additional participant recruitment or intervention. Helsinki Yes Informed Consent Yes
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