Chronic Fibrosis in Lower Urinary Tract Dysfunctions—Mechanisms and Therapeutic Options

Workshop 8

Workshop Schedule

09:00

Marcus John Drake

09:20

Lori A Birder

09:40

Anthony John Kanai

10:00

Christopher Henry Fry

10:20

All

Aims & Objectives

Advanced
90 minutes
Neurourology
Basic Science / Translational
Bladder Fibrosis Radiation & Ketamine Cystitis Underactive Bladder
Scientists, urologists and other healthcare workers interested in new mechanistic concepts and treatments for chronic fibrosis in lower urinary tract dysfunctions (LUTD).
This workshop will provide the latest information on the pathophysiology and clinical implications of chronic fibrosis in LUTD including radiation and ketamine cystitis, underactive bladder, bladder obstruction and congenital anomalies. The workshop will consider how changes to the quantity and subtype profiles of collagen and its deposition in the extracellular matrix (ECM) of the bladder wall will impact on changes to compliance, passive tension and active and spontaneous force generation. The therapeutic benefits and mode of action of antifibrotic agents, including the hormone, relaxin, in rescuing these pathological conditions will be presented.