|
Research Type
|
Pure and Applied Science / Translational |
|
Keywords
|
Bladder Fibrosis Radiation & Ketamine Cystitis Underactive Bladder |
|
Target Audience
|
Scientists, urologists and other healthcare workers interested in new mechanistic concepts and treatments for chronic fibrosis in lower urinary tract dysfunctions (LUTD). |
|
Aims and Objectives
|
This workshop will provide the latest information on the pathophysiology and clinical implications of chronic fibrosis in LUTD including radiation and ketamine cystitis, underactive bladder, bladder obstruction and congenital anomalies. The workshop will consider how changes to the quantity and subtype profiles of collagen and its deposition in the extracellular matrix (ECM) of the bladder wall will impact on changes to compliance, passive tension and active and spontaneous force generation. The therapeutic benefits and mode of action of antifibrotic agents, including the hormone, relaxin, in rescuing these pathological conditions will be presented.
Learning Objectives - 1) Provide up to date information on the clinical implications of chronic fibrosis in LUTD.
2) Discuss mechanisms that contribute to inflammation, collagen deposition and alterations in the ECM leading to chronic fibrosis.
3) Show findings of the therapeutic benefits of anti-fibrotic agents to increase wall compliance and enhance contractile function of bladders with increased ECM deposition.
4) Consider the cellular pathways that regulate ECM deposition.
|