Underactive Bladder—Clinical Implications, Mechanistic Concepts and Therapeutic Options

Workshop 13

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Workshop Schedule


Marcus John Drake


Lori A Birder


Anthony John Kanai


Christopher Henry Fry


Anthony John Kanai
Marcus John Drake
Lori A Birder
Christopher Henry Fry

Aims & Objectives

90 minutes
Pure and Applied Science / Translational
detrusor underactivity and lower urinary tract dysfunction Ageing, ischemia, free radicals and mitochondrial autophagy inflammation, fibrosis and relaxin
Scientists, urologists and other healthcare workers interested in the diagnosis, pathophysiology and treatment of underactive bladder (UAB).

This workshop will present up to date information on the clinical description and diagnosis of UAB, associated co-morbidities, its pathophysiology and new drug targets. Topics will include: the pathological implications of aging; bladder ischemia, inflammation and fibrosis; their impact on decreased detrusor force generation and/or contractility; and the involvement of free radical formation and mitophagy. The therapeutic relevance of free-radical scavengers, as well as anti-inflammatory and antifibrotic agents will be discussed.

Learning Objectives

  • 1) Provide up-to-date information on the clinical implications of UAB as a cause of impaired bladder emptying in the elderly population and in young women afflicted with Fowler’s syndrome. This workshop will enhance our understanding of the basic science of ageing and will provide knowledge to develop strategies that will increase the ‘health-span’ of the ageing adult. 2) Identify comorbidities associated with UAB, discuss relevant animal models and show findings on the therapeutic benefits of free radical scavengers, anti-inflammatory and antifibrotic agents on the underactive bladder. 3) Characterise cellular pathways and mechanisms of action that may be responsible for UAB and whether they involve altered detrusor force generation and/or bladder sensation.