|Research Type||Basic Science / Translational|
|Keywords||Detrusor underactivity and lower urinary tract dysfunction Ageing, ischemia, free radicals and mitochondrial autophagy Inflammation, fibrosis and relaxin|
|Target Audience||Scientists, urologists and other healthcare workers interested in the diagnosis, pathophysiology and treatment of underactive bladder (UAB).|
|Aims and Objectives|
This workshop will present up to date information on the clinical description and diagnosis of UAB, associated co-morbidities, its pathophysiology and new drug targets. Topics will include: the pathological implications of aging; bladder ischemia, inflammation and fibrosis; their impact on decreased detrusor force generation and/or contractility; and the involvement of free radical formation and mitophagy. The therapeutic relevance of free-radical scavengers, as well as anti-inflammatory and antifibrotic agents will be discussed.