RCT TOT vs ULP (urethral ligament plication ) operation for cure of SUI

Esercan A1, Sivaslioglu A2, Petros P3

Research Type

Clinical

Abstract Category

Female Stress Urinary Incontinence (SUI)

Abstract 73
Surgical Videos 1
Scientific Podium Video Session 7
Thursday 18th September 2025
14:00 - 14:07
Parallel Hall 2
Anatomy Female Stress Urinary Incontinence Surgery
1. Sanliurfa Research and TRaining Hospital, 2. MUgla University Turkey, 3. Retired pelvic surgeon
Presenter
Links

Abstract

Introduction
The ULP (urethral ligament plication ) is a new operation for cure of SUI which does not require a tape. The ULP operation is based on a live anatomical study of the PUL (pubourethral ligament) [1] and the same restoration of the two closure mechanisms behind the TVT MUS (midurethral sling) [2].   Fundamental to both MUS and ULP operations is the surgical principle developed in experimental animals, harnessing the tissue reaction of an implanted foreign body (such as a tape), to create neocollagen to reinforce weakened PULs [3]and to prevent the PUL lengthening during effort which opens bladder neck to cause urine loss on effort . Whereas the MUS creates an entirely new PUL neoligament, the ULP operation’s wide-bore polyester sutures confine all 4 branches of the PUL to prevent elongation, and add new collagen to strengthen the ligaments .
Design
Patients were computer randomized. Registration, EC and informed consent obtained, no funding. TOT technique : standard outside/in.  ULP Learning curve:11 patients.
ULP Technique  Two 4cm incisions were made in the distal vaginal sulci, from external urethral meatus to bladder neck. A No 2 collagen-creating polyester suture was inserted  into the 4 PUL attachment points, Figure1 (right). The sagittal view, left, shows a single suture confining all 4 parts of PUL .
Caption 
Figure 1 Surgical repair PUL, single wide-bore polyester suture, sagittal & frontal views 
Right - live anatomy:   PUL insertions and suture attachments: 1: medial to PUL; 2: behind symphysis: origins of PUL, PVL (pubovesical ligament-not shown); 3:EUL. 4: lateral attachment to PCM. Tape measure shows the surgery is carried out in a 4 sq.cm space.
 
Left cadaver figure Suture confines 4  PUL insertion points: A=anterior pubourethral ligament (EUL); I=intermediate pubourethral ligament; P=posterior pubourethral ligament; LA=levator ani (m. pubococcygeus);; SP=symphysis pubis; U=urethra; EUM=external meatus; (by permission, Robert Zacharin).
Results
RESULTS  at 12 months
The ULP was superior to conventional TOT in all measures
•	Cure rates: 90.7% cure vs 81.5% (p<0.05);  UDI6 0.61 vs 1.17; 
•	Operating time 18 minutes vs 26 minutes; 
•	Complications TOT: pain 7.4%; mesh extrusion trimming (7.4%) with 50% failure. ULP: nil important .
Conclusion
•	low cost ($2 for polyester sutures);
•	safe, direct vision surgery (no blind insertion instruments to damage organs, nerves,blood vessels) 
•	minimal facilities 
•	local anesthetic option
•	especially suited to emerging nations.
Figure 1 Figure 1 Surgical repair PUL, single wide-bore polyester suture, sagittal & frontal views
References
  1. . Petros PE. The pubourethral ligaments-an anatomical and histological study in the live patient. Int Urogynecol J. 1998;9:154-157
  2. . Petros PE, Ulmsten U. An Integral Theory of female urinary incontinence. Acta Obstet Gynecol Scand. 1990;69 Suppl 153:1-79.
  3. Petros PE, Ulmsten U, Papadimitriou J. The Autogenic Neoligament procedure: A technique for planned formation of an artificial neo-ligament. Acta Obstet Gyn Scan. 1990;69 Suppl 153:43-51.
Disclosures
Funding No funding Clinical Trial Yes Registration Number clinical trials gov ID NCT06232525 RCT Yes Subjects Human Ethics Committee HARRAN UNIVERSITESI KLINIK ARASTIMLARAR. ETIK KURUL KARARI Helsinki Yes Informed Consent Yes
02/07/2025 16:02:14