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Prof Osamu Ishizuka
Shinshu University

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Osamu Ishizuka

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Profession:Urologist
Qualifications:Professor Chairman of Department/Section PhD
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Original Articles

1.Ishizuka,O., Igawa,Y., Mattiasson, A. and Andersson, K.-E.: Capsaicin-induced bladder
hyperactivity in normal conscious rats. J.Urol.,152:525-530,1994.

  1. Ishizuka,O., Igawa,Y., Lecci, A., Maggi, C. A., Mattiasson, A. and Andersson, K.-E.:
    Role of intrathecal tachykinins for micturition in unanaesthetized rats with and
    without bladder outlet obstruction. Br.J.Pharmacol.,113:111-116,1994.

  2. Ishizuka,O., Mattiasson, A. and Andersson, K.-E.: Prostaglandin E2-induced, bladder
    hyperactivity in normal conscious rat. Involvement of tachykinins? J.Urol.,153:2034-
    2038,1995.

  3. Ishizuka,O., Alm, P., Larsson, B., Mattiasson, A. and Andersson, K.-E.: Facilitatory
    effect of pituitary adenylate cyclase activating polypeptide on micturition in normal,
    conscious rats. Neuroscience, 66:1009-1014,1995.

  4. Ishizuka,O., Mattiasson, A. and Andersson, K.-E.: Tachykinin effects on bladder
    activity in conscious, normal rats. J.Urol., 154:257-261,1995.

  5. Ishizuka,O., Mattiasson, A. and Andersson, K.-E.: Urodynamic effects of intravesical
    resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction.
    J.Urol., 154:611-616,1995.

  6. Ishizuka,O., Mattiasson, A. and Andersson, K.-E.: Effects of neurokinin receptor
    antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.
    J.Urol.,154:1548-1551, 1995.

  7. Ishizuka,O., Persson, K., Mattiasson, A., Naylor, A., Wyllie, M. and Andersson, K.-E.:
    Micturition in conscious rats with and without outlet obstruction: role of spinal 1
    adrenoceptors. Br.J.Pharmacol.,117:962-966,1996.

  8. Ishizuka,O., Mattiasson, A. and Andersson, K.-E.: Role of spinal and peripheral 2
    adrenoceptors in micturition in normal conscious rats. J.Urol.,156:1853-1857,1996.

  9. Ishizuka,O., Mattiasson, A., Steers, W. D. and Andersson, K.-E.: Effects of spinal 1
    adrenoceptors blockade on bladder activity induced by apomorphine in conscious rats
    with and without outlet obstruction. Neurourol.Urodyn.,16:191-200,1997.

  10. Ishizuka,O., Pandita, R.K., Mattiasson, A., Steers, W. D. and Andersson, K.-E.:
    Stimulation of bladder activity by volume, l-dopa and capsaicin in normal conscious
    rats - effects of spinal 1-adrenoceptors blockade. Naunyn-Schmiedeberg's Arch.
    Pharmacol., 355:787-793,1997.

  11. Komiyama,I., Igawa,Y., Ishizuka,O., Nishizawa,O. and Andersson, K.-E.: Effects of
    intravesical capsaicin and resiniferatoxin on distension-induced bladder contractility in
    conscious rats with and without chronic spinal cord injury. J.Urol.,161:314-319, 1999.

  12. Ishizuka,O., Igawa,Y., Nishizawa, O. and Andersson, K.-E.: Role of supraspinal
    tachykinins for volume and l-DOPA induced bladder activity in normal conscious rats.
    Neurourol.Urodyn. 19:101-109,2000.

  13. Gu, B. -J., Ishizuka, O., Igawa, Y., Nishizawa, O., Andersson, K.-E.: Role of supraspinal
    tachykinins for micturition in conscious rats with and without bladder outlet
    obstruction. Naunyn-Schmiedeberg's Arch.Pharmacol.361(5):543-548,2000

  14. Seki, S., Igawa, Y., Kaidoh, K., Ishizuka, O., Nishizawa, O. and Andersson, K.-E.: Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats.
    Neurouro Urodyn. 20: 105-113, 2001.

  15. Gu, B. -J., Ishizuka, O., Igawa, Y., Nishizawa, O., Andersson, K.-E.: Role of supraspinal
    1-adrenoceptors for micturition in conscious rats with and without bladder outlet
    obstruction. J.Urol. 167: 1887-1891, 2002.

  16. Homma,Y., Ando, T., Yoshida, M.,Kageyama,S., Takei,M., Kimoto,K., Ishizuka, O.,
    Gotoh, M. and Hshimoto,T.: Voiding and incontinence frequencies: variability of
    diary data and required diary length. Neurourol. Urodyn. 21: 204-209, 2002.

  17. Ishizuka,O., Gu, B.-J., Igawa, Y., Nishizawa, O., Pehrson, R., Andersson, K.-E.: Role of
    supraspinal serotonin receptors for micturition in normal conscious rats. Neurourol.
    Urodyn. 21: 225-230, 2002.

  18. Ishizuka, O., Gu, B.-J., Nishizawa, O., Mizusawa, H., Andersson, K.-E.: Effect of
    apomorphine on intracavernous pressure and blood pressure in conscious,
    spinalized rats. Int.J.Imp.Res. 14(2): 128-132, 2002.

  19. Ishizuka,O., Iijima,K., Ishikawa,M., Hirakata, S., Nagai, T., Ueki, T., Nishizawa, O.:
    Importance of Transition Zone Biopsies in Patients Undergoing Ultrasound-guided
    Prostate Systemic Biopsies for the First Time. Urol.Int. 69:102-105, 2002.

  20. Ishizuka,O., Gu, B.-J., Young, Z.-X, Nishizawa, O., Andersson, K.-E.: Functional role of
    central muscarinic receptors for micturition in normal conscious rats. J.Urol.,
    168 (11): 2258-2262, 2002.

  21. Person,R., Ojteg, G., Ishizuka,O. and Andersson,K.-E.: Effects of NAD-299,
    a new, highly selective 5-HT1A receptor antagonist, on bladder function in rats.
    Naunyn-Schmiedeberg's Arch.Pharmacol. 366: 528-536, 2002.

  22. Igawa,Y., Satoh,T., Mizusawa,H., Seki,S., Kato,H., Ishizuka,O., Nishizawa,O.: The role
    of capsaicin-sensitive afferents for autonomic dysreflexia in patients with spinal cord
    injury. BJU int 91(7): 637-41, 2003.

  23. Zhang, X.Y, Igawa,Y., Ishizuka,O., Nishizawa, O. and Andersson, K.E.: Effects of resiniferatoxin desensitization of capsaicin-sensitive afferents on detrusor over-activity induced by intravesical capsaicin, acetic acid or ATP in conscious rats. Naunyn-Schmiedeberg's Arch.Pharmacol. 367:473-479, 2003.

  24. Ishizuka,O., Mimura, Y., Oguchi, T., Kawakami, M. and Nishizawa,O.: Importance of transition zone prostate biopsies in patients with gray-zone PSA levels undergoing the ultrasound-guided systematic ten-biopsy regimen for the first time. Urol.Int. 74 (1): 23-26, 2005.

  25. Ishizuka,O., Tanabe, T., Nakayama, T., Kawakami, M., Kinebuchi, Y. and Nishizawa,O.:
    Prostate-specific antigen, Gleason sum and clinical T stage for predicting the need for radionuclide bone scan for prostate cancer patients in Japan. Int. J. Urol. 12:728-732, 2005.

  26. Zhang, X.Y., Ishizuka, O., Tanabe, T., Satoh, T., Nakayama, T., Imamura, T., Nishizawa,
    O.: Effects of goshajinkigan (Niu-Che-Sen-Qi-Wan) for resiniferatoxin-sensitive afferents
    on detrusor overactivity induced by acetic acid in conscious rats. Am.J.Chi.Med.
    34(2): 285-293, 2006.

  27. Aizawa, N., Ishizuka, O., Ogawa, T., Mizusawa, H., Igawa, Y., Nishizawa, O.: Role of 5-HT receptor antagonists in mediating intracavernous pressure response induced by fluvoxamine in conscisous rats. J.Sex.Med. 4: 1108-1116, 2007.

  28. Yamaguchi, O., Marui, E., Kakizaki, H., Itoh, N., Yokota, T., Okada, H., Ishizuka, O., Ozono, S., Gotoh, M., Sugiyama, T., Seki, N., Yoshida, M.: Randomized, double-blind, placebo- and propiverine- controlled trial of the once-daily antimuscarinic agent solifenacin in Japanese patients with overactive bladder. BJUint., 100: 579-587, 2007.

  29. Ichino, M., Igawa, Y., Seki, S., Iijima, K., Ishizuka, O., Nishizawa, O.: The nature of high-pressure voiding in small boys and its relation with the influence of a transurethral catheter. Neurouro Urodyn. 27(4): 319-323, 2007.

  30. Imamura, T., Ishizuka, O., Aizawa, N., Zhong, C., Ogawa, T., Nakayama, T., Tanabe, T., Nishizawa, O.: Cold environmental stress induced detrusor overactivity via resiniferatoxin-sensitive nerves in conscious rats. Neurouro Urodyn. 27(4): 348-352, 2007.

  31. Ichino M, Igawa Y, Seki S, Ishizuka O, Nishizawa O.: Natural History and Etiology of High Pressure Voiding in Male Infants. J Urol., 178:2561-2566, 2007.

  32. Imamura, T., Kinebuchi, Y., Ishizuka, O., Seki, S., Igawa, Y., Nishizawa, O.: Implantation of mouse bone marrow cells reconstructs layered smooth muscle structures in injured urinary bladder. Cell transplantation 17: 267-278, 2008.

  33. Aizawa, N., Ishizuka, O., Ogawa, T., Mizusawa, H., Igawa, Y., Nishizawa, O., Anderssson K.E.: Effects of natriuretic peptides on intracavernous pressure and blood pressure in conscious rats. J.Sex.Med. 5: 2312-2317, 2008

  34. Imamura, T., Ishizuka, O., Aizawa, N., Zhong, C., Ogawa, T., Nakayama, T., Tanabe, T., Nishizawa, O.: Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C-fiber activation induced by acetic acid in rat bladder. Neurourol Urodyn. 27: 832-837, 2008.

  35. Chen, Z., Ishizuka, O., Imamura, T., Aizawa, N., Igawa, Y., Nishizawa, O., Andersson, K.E.: Role of 1-adrenergic receptors in detrusor overactivity induced by cold stress in conscious rats. Neurourol Urodyn. 28: 251-256, 2008.

  36. Imamura, T., Ishizuka, O., Zhong, C., Ogawa, T., Nakayama, T., Kurizaki, Y., Tanabe, T., Nishizawa, O., Andersson, K.-E.: An Extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins and P2X3 and TRPV1 receptors and inihibits ATP-induced detrusor overactivity in spontaneously hypertensive rats. Neurourol Urodyn. 28: 529-534, 2009.

  37. Imamura, T., Yamamoto, T., Ishizuka, O., Goto, M., Nishizawa, O.: The microenvironment of freeze-injured mouse urinary bladders enables successful tissue engineering. Tissue Eng. 15(11): 3367-3375, 2009.

  38. Chen, Z., Ishizuka, O., Imamura, T., Aizawa, N., Kurizaki, Y., Igawa, Y., Nishizawa, O.: Stimulation of skin menthol receptors stimulates detrusor activity in conscious rats. Neurourol Urodyn. 29: 506-511, 2010.

  39. Ogawa, T., Nishizawa, O., Chen, Z., Ishizuka, O., Seki, S., Imamura, T., Akahane, S., Honma, T., Honma, Y.: Over-expression of CXCR-3-binding chemokines and TNFSF14 in bladder urothelium from patients with ulcerative interstitial cystitis. J.Urol. 183: 1206-1212, 2009

  40. Minagawa, T., Imamura, T.,Ishizuka, O., Igawa, Y., Nishizawa,O. : Differentiation of smooth muscle cells from human amniotic mesechymal cells implanted in the

  41. Kinebuchi, Y., Aizawa, N., Imamura, T., Ishizuka, O., Igawa, Y., Nishizawa, O.: Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter. Int.J.Urol. 17:359-368, 2010.

  42. Nakayama, T., Imamura, T., Ishizuka, O., Nishizawa, O.: Expression of 1-adrenergic receptor subtypes and angitensin Ⅱ type 1 receptor in the prostate of spontaneously hypertensive rats. 信州医誌 58(3):103-114, 2010.

  43. Mimura, Y., Imamura, T., Kinebuchi, Y., Aizawa, N., Ishizuka, O., Nishizawa, O.: Rat bladders augmented with a novel bovine pericardium-derived biomaterial reconstruct functional tissue structures. LUTS 2: 76-82, 2010.

  44. Minagawa, T., Murata, Y., Uehara, T., Imamura, T., Ishizuka, O.: Impact of high-consisitency area evaluated under hand-operated transrectal compression using a sonographic probe on prostate cancer detection: Clinicopathological analysis. Int.J.Urol. 17(10): 876-880, 2010.

  45. Kurizaki, Y., Ishizuka, O., Imamura, T., Ichino, M., Ogawa, T., Igawa, Y., Nishizawa, O., Andersson, K.E.: Relation between expression of 1-adrenoceptor mRNAs in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms. Scand.J.Urol.Nephrol. 45: 15-19, 2011.

  46. Imamura, T., Ishizuka, O., Kinebuchi, Y., Kurizaki, Y., Nakayama, T., Ishikawa, M., Nishizawa, O.: Implantation of autologous bone marrow-derived cells reconstructs functional urethral sphincters in rabbits. Tissue Eng. Part A 2011 Apr; 17(7-8): 1069-81. Epub 2011 Jan 16.

  47. Ishizuka, O., Nishizawa, O., Takeda, M., Nomura, T., Kagawa, S.: Early efficacy of an alpha 1 adrenoceptor antagonist, naftopidil, againt lower urinary tract symptoms suggestive of benign prostatic hyperplasia. LUTS 3: 79-85, 2011.

  48. Tanabe, T., Ishizuka, O., Ichino, M., Ogawa, T., Imamura, T., Kurizaki, Y., Iijima, K.,
    Nishizawa, O.: Analysis of the pressure-flow study in weak detrusor patients with benign prostatic hypertrophy. LUTS 3: 109-112, 2011.

  49. Yokoyama, O., Yamaguchi, O., Kakizaki, H., Itoh, N., Yokota, T., Okada, H.,
    Ishizuka, O., Ozono, S., Gotoh, M., Sugiyama, T., Seki, N., Yoshida, M., Yamada, S.: Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. J Urol. 186(1): 170-174, 2011.

  50. Ishikawa, M., Imamura, T., Ishizuka, O., Kurizaki, Y., Noguchi, W., Zhang, L.,
    Nishizawa, O.: A galenical of traditional chinese herberl mixture (THC-002) reduces expression of tachykinin peptides within urethras of spontaneously hypertensive rats. Neuroruol. Urodyn. 31:201-206, 2012

  51. Inoue, H., Ishizuka, O., Imamura, T., Yamagishi, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O.: The relationship between toe temperature and lower urinary tract symptoms. LUTS 4(3): 144-149, 2012.

  52. Imamura, T., Ishizuka, O., Zhang, L., Hida, S., Sudha, G.S., Kato, H., Nishizawa, O.: Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructe functional bladder tissues in rats. Tissue Eng Part A. 18(15-16): 1698-709, 2012.

  53. Ishizuka, O., Nishizawa, O., Nishizawa, S., Satoh, T., Wajiki, M., Kiyokawa, H., Inoue, Y., Kobayashi, S., Mizusawa, H., Nakagawa, T.: Comparison of efficacy and safety of one- and three-month luteinizing hormone-releaseing hormone agonist depots as initial therapies for prostate cancer. I.J.Clin.Oncol. 18: 524-530, 2013.

  54. Kurizaki, Y., Ishizuka, O., Imamura, T., Nishizawa, O., Andersson,K.-E. Relationship between expression of 3-adrencoceptor mRNA in bladder mucosa and urodynaic findings in men with lower urinary tract symptoms. Neurourol. Urodyn. 32: 88-91, 2013.

  55. Kurizaki, Y., Ishizuka, O., Imamura, T., Ichino, M., Nishizawa, O.: Correlation between
    bladder mucosal alpha 1D/alpha-1A adrenoceptor mRNA ratio and lower urinary tract function in benign prostatic obstruction patients. LUTS 5(2): 60-64, 2013.

  56. Ishizuka, O., Matsuyama, H., Sakai, H., Matsubara, A., Nagaoka, A., Takahashi, S., Takeda, M., Ozono,S., Shiroki,R., Shuin, T., Hara, I., Kakizaki, H., Tsukamoto, T., Yamanishi, T., Yokoyama, O., Kakehi, Y., Nishizawa, O.: Nocturia potentially influences maintenance of sexual function in elderly men with benign prostatic hyperplasia. LUTS 5(2): 75-81, 2013.

  57. Imamura, T., Ishizuka, O., Sudha, G.S., Lei, Z., Hosada, T., Noguchi, W., Yamagishi, T., Kurizaki, Y., Nishizawa, O.: A galenical produced from Ba-Wei-Huang-Wan (THC-002) provide resistance to the cold stress-induced detrusor overactivity in conscious rats. Neurourol. Urodyn. 32:486-492, 2013.

  58. Lei, Z., , Ishizuka, O., Imamura , T., Noguchi, Q., Yamagishi , T., Yokoyama, H., Kurizaki, Y., Sudha, G.S., Hosoda, T., Nishizawa, O., Andersson, K.E: Functional roles of transient receptor potentila melastatin 8 (TRPM8) in the cold stress-induced detrusor overactivity pathways in conscious rats. Neurourol. Urodyn. 32:500-504, 2013.

  59. Noguchi,W., Ishizuka,O., Imamura, T., Kurizaki, Y., Yamagishi, T., Yokoyama, H., Zhang, L., Sudha, GS, Nishizawa,O., Andersson,KE: The relationship between alpha1-adrenergic receptors and TRPM8 channels in detrusor overactivity induced by cold stress in ovariectomized rats. J.Urol. 189(5): 1975-1981, 2013.

  60. Suzuki,H., Suzuki,T., Ishizuka,O., Nishizawa, O., Ueno,M.: Efficacy and safety of advanced renal cell carcinoma patients treated with sorefenib: roles of cytokine pretreatment. I.J.Clin.Oncol. 19: 686-692, 2014.

  61. Sudha, G.S., Imamura, T., Ishizuka, O., Zhang, L., Yamagishi, T., Yokoyama, H., Minagawa, T., Ogawa, T., Kurizaki, Y., Kato, H., Nishizawa, O.: Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra. Tissue Eng. Part A. 20(13-14): 1971-9, 2014.

  62. Minagawa, T., Ishizuka, O., Nishizawa, O.: Observation of the interureteric ridge and
    ureteral origice in a patient with a cystocole using color Doppler ultrasonography via the prolapsed bladder. J Med Ultrasonics 41: 533-534, 2014.

  63. Yamagishi, T., Ishizuka, O., Imamura, T., Yokoyama, H., Ogawa, T., Kurizaki, Y., Nishizawa, O., Andersson, K.E.: Alpha1-adrenergic receptors mediate detrusor overactivity induced by cold stress in rats with bladder outlet obstruction. Neurourol. Urodyn. 34:280-285, 2015.

  64. Minagawa, T., Ogawa, T., Ishizuka, O., Nishizawa, O.: Impact of dynamic ultrasonography on pelvic organ prolapse. J. Urol. 193(2): 670-6, 2015.

  65. Yokoyama, H., Hara, H., Ogawa,T., Ishizuka, O.: Acute cholecystitis after urological surgery: A report of 11 cases in our department and a review of the literature. J Clin Urol. 1-6: 2015.

  66. Imamura, T., Ishizuka, O., Ogawa, T., Yamagishi, T., Yokoyama, H., Minagawa, T., Nakazawa, M., Sudha, S.G., Nishizawa, O.: Muscarinic receptors mediate cold stress-induced detrusor overactivity in type 2 diabetes mellitus rats. IJU 21(10): 1051-1058: 2014.

  67. Imamura, T., Ogawa, T., Minagawa, T., Yokoyama, H., Nakazawa, M., Nishizawa, O., Ishizuka, O.: Engineered Bone Marrow-derived cell sheets restore structure and function of radiation-injured rat urinary bladder. Tissue Eng. Part A 21(9-10): 1600-1610, 2015. 10.1089/ten.TEA.2014.0592.

  68. Yokoyama, O., Yamagishi, A., Yoshida, M., Yamanishi, T., Ishizuka, O., Seki, N., Takahashi, S., Yamaguchi, O., Higo, N., Minami, H., Masegi, Y.: Once-daily oxybutynin patch improves nocturia and sleep quality in Japanese patients with overactive bladder: Post-hoc analysis of a phase Ⅲ randomized clinical trial. Int.J.Urol. 22(7): 684-688, 2015.

  69. Imamura, T., Ishizuka, O., Ogawa, T., Yamagishi, T., Yokoyama, H., Minagawa, T., Nakazawa, M., Nishizawa, O.: Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-induced Detrusor Overactivity in Conscious Rats. LUTS 7(1): 50-55, 2015

  70. Imamura, T., Ishizuka, O., Ogawa, T., Minagawa, T., Ishikawa, M., Hiragata, S., Yokoyama, H., Nakazawa, M., Kurizaki, Y., Nishizawa, O.: Expression of 5-hydroxytrptamine receptors in human urinary bladders with benign prostatic hyperplasia. Adv. Ther. 32 (suppl 1): 29-37, 2015. DOI 10.1007/s12325-015-0242-0 IF:2.272

  71. Minagawa, T., Suzuki, T., Domen, T., Yokoyama, H., Ishikawa, M., Hirakata,S., Nagai,
    T., Nakazawa, M., Ogawa,T., Ishizuka,O.: Modified sonourethrography assists urethral
    catheterization. J Med Ultrasonics 43:443-448, 2016.

  72. Imamura, T., Ogawa, T., Minagawa, T., Nagai, T., Suzuki,T., Saito,T., Yokoyama,H., Nakazawa, M., Ishizuka,O.: Combined treatment with a 3-adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats. Neurourol.Urodyn. 36(4): 1026-1033, 2017.

  73. Minagawa, T., Saitoh, T., Suzuki, T., Domen, T., Yokoyama, H., Ishikawa, M., Hirakata,
    S., Nagai, T., Nakazawa, M., Ishizuka,O.: Impact of ao-dake-humi, Japanese traditional
    bamboo foot stimulator, on lower urinary tract symptoms, constipation and
    hypersensitivity to cold: a single-arm prospective pilot study. BMC Complementary
    and Alternative Medicine 16:513-520, 2016.

  74. Ishikawa, M., Imamura, T., Nishizawa, O., Ishizuka,O.: Implantation of autologous
    bone marrow-derived cells improve erectile dysfunction in spontaneously
    hypertensive rats. Shinshu Medical Journal 65(1):37-44, 2017.

  75. Shimizu, S., Yamamoto, T., Nakayama, S., Hirakawa, A., Kuwatsuka, Y., Funahashi, Y., Matsuoka, Y., Takanari, K., Toriyama, K., Kamei, Y., Narimoto, K., Yamanishi, T., Ishizuka, O., Mizuno, M., Gotoh, M.: Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol. BMC Urology 17:89; 2017. DOI 10.1186/s12894-017-0282-7

  76. Minagawa, T., Daimon, H., Ogawa, N., Saito, T., Suzuki, T., Domen, T., Nagai, T.,
    Ogawa, T., Ishizuka, O.: Morphological and clinical evaluation of prostatic urethra using modified sonourethrography with retrograde jelly injection. LUTS 11(2): 4-10, 2019.

  77. Imamura, T., Shimamura, S., Ogawa, T., Minagawa, T., Nagai, T., Silwal Gautam, S., Ishizuka, O.: Biofabricated structures reconstruct functional urinary bladders in radiation -injured rat bladders. Tissue Eng. Part A 2018 Nov; 24 (21-22):1574-1587 doi: 10.1089/ten.TEA.2017.0533. Epub 2018 Jun 29. PMID: 29737234

  78. Masaki, K., Sakai, M., Kuroki, S., Jo, JI, Hoshina, K., Fujimori, Y., Oka, K., Amano, T.,
    Yamanaka, T., Tachibana, M., Tabata, Y., Shiozawa, T., Ishizuka, O., Hochi S, Takashima, S.: FGF2 has distinct molecular functions from GDNF in the mouse germline niche. Stem Cell Reports. 2018 Jun 5;10(6):1782-1792.

  79. Suzuki, T., Hattori, R., Minagawa, T., Uehara, T., Ogawa, T., Ishizuka, O.: Intestinal injury by heat conduction from surgical sealing devices. JSLS 2019 Jan-Mar; 23(1). pii: e2018.00100. doi: 10.4293/JSLS.2018.00100. PMID:30846895 

  80. Minagawa, T., Ogawa, T., Ishizuka, O.: Fluid dynamic assessment of the lower urinary
    tract: Exploratory research to observe vorticity in the prostatic urethra after transurethral enucleation. Int J Urol 2019 26(8):853-854.

  81. Nagai, T., Imamura, T., Ogawa, T., Minagawa,T., Domen,T., Suzuki, T., Ueno, M., Ishizuka, O. : Nicotine-induced hypoxia in rat urotherium deteriorates bladder storage funcitons. Neurourol., Udoryn. 2019 38(6):1560-1570.

  82. Minagawa, T., Tezuka, M., Ogawa, T., Ishizuka, O.: Vorticity in lower urinary tract can
    be assessed and associates with urinary tract morphology in men. Neurourol. Urodyn.,
    2020 39(1): 286-294.

  83. Yokomizo, A., Wakabayashi,M., Satoh, T., Hashine, K., Inoue,T., Fujimoto,K., Egawa,S., Habuchi,T., Kawashima,K., Ishizuka,O., Shinohara,N., Sugimoto,M., Yoshino,Y., Nihei,K., Fukuda,H., Tobisu, K., Kekehi, Y., Naito,S.: Salvage radiotherapy versus hormone therapy for prostate-specific antigen failure after radical prostatectomy: A randomized, multicenter, open-label, phase 3 trial (JCOG401). Eur. Urol. 77(6): 689-698, 2020

  84. Yamamoto, T., Ishizuka, O., Oike, H., Shiozaki, M., Haba, T., Oguchi, T., Iijima, K., Kato, H.: Safety and efficacy of cabazitaxel in Japanese patients with castration-resistant prostate cancer. Prostate International 8:27-33, 2020

  85. Ueno, M., Minagawa, T., Saito, T., Imamura, T., Nagai, T., Ogawa, T., Ishizuka, O.: The therepeutic effect of Choreito, a traditional Japanese (Kampo) medicine in Japan, on overactive bladder induced by acetic acid in the rats. Low Urin Tract Symptoms 12(3): 198-205, 2020.

  86. Hashimoto, K., Harada, M., Yamada, Y., Sugano, M., Minagawa, T., Ogawa, T., Ishizuka, O., Kamijo, Y.: Adequacy of decision-making based on each kidney function estimation method for Japanese living kidney donor candidates: a retrospective observational study. Renal Replacement Therapy (in press)

  87. Gotoh, M., Shimizu, S., Yamamoto, T., Ishizuka, O., Yamanishi, T., Mizokami, A., Narimoto, K., Toriyama, K., Kamei, Y., Nakayama, S., Kuwatsuka, Y., Mizuno, M., Hirakawa, A.: Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study. Int J Urol. 2020 Jul 30. doi: 10.1111/iju.14311. Online ahead of print.

  88. Sudha, S.G., Imamura, T., Shimamura, M., Minagawa, T., Nakazawa, M., Ogawa, T., Ishizuka, O., Recovery of cryo-injured rabbit urethra by biofabricated c-shaped adipose-derived mesenchymal cell structures. Shinshu Med J 68(6): 357-370, 2020.

Case Reports

  1. Ishizuka, O., Ogawa, A. and Oohashi, M.: Renovascular hypertension associated with
    narrowing of the infrarenal aorta. BJU int., 64:98-99, 1989.

  2. Ishizuka, O., Misawa, K., Nakazawa, M., Nishizawa, O.: Retroperitoneal bronchogenic
    cyst: laparoscopic treatment. Urol. Int. 72: 269-270, 2004.

  3. Irie, K., Ishizuka, O., Yokoyama, H, Kinebuchi, Y, Satoh, T., Nishizawa, O.: Resection of
    local recurrence of renal cell carcinoma in a haemodialysis patients 6 years afte radical
    nephrectomy. Int. J. Urol. 11: 550-552, 2004.

  4. Yamamoto, K., Kato, N., Oide, T, Ishizuka, O, Ikeda, S.: Sucessful pharmacotherapy for
    an adult case with prolonged symptoms of postganglionic chokinergic dysautonomia.
    Eur.Neurol. 51(4): 244-246, 2004.

  5. Higuchi M, Hata T, Furuya S, Hosaka S, Kamijo Y, Kiyosawa K, Ishizuka O,
    Nishizawa O, Hora K: Epstein-Barr virus-related primary central nervous system lymphoma after cadaveric renal transplantation improved by treatment with high-dose methotrexate followed by irradiation. Nephrology 10(3):321-324, 2005.

  6. Mizusawa, H., Ishizuka, O., Igawa, Y., Komiyama, M., Iwata, K., Nishizawa, O.: Improvement of polyuria, bladder sensation and bladder capacity following renal transplantation. Int.J.Urol. 13 (5): 614-616, 2006.

  7. Ishizuka, O., Takayama, F., Sone, S.: Large renal aneurysm successfully treated by
    percutaneous embolization using controlled detachable coils. Int.J.Urol. 13: 993-994, 2006.

  8. Ishikawa, M., Ishizuka, O., Nakayama, T., Kobayashi, S., Igawa, Y., Nishizawa, O.,
    Sugimoto, K., Yamashita, T., Matsushita, T.: Alveolar soft part sarcoma of the retroperitoneum. Int.J.Urol.13(10): 1355-1357, 2006

  9. Kinebuchi, Y., Ishikawa, M., Ishizuka, O., Nishizawa, O., Hongo, K.: Leptomeningeal metastasis in a patient with an extragonadal germ cell tumor. Clinical Medicine Oncology, 2:371-374: 2008.

  10. Saito, T., Nishizawa, O., Ishikawa, M, Simojima, Y., Oguchi, T., Suzuki, H., Yokoyama,
    H., Ichino, M., Kato, H., Ishizuka, O. Secondary tranobturator tape (TOT) procedure
    after combined pelvic organ prolapse repair. LUTS 5: 52-54, 2013.

  11. Mingawa, T., Ishizuka, O., Nishizawa, O.: Observation of the interureteric ridge and ureteral orfice in the patient with cystocele using color Doppler ultrasonography via the prolapsed bladder. J Med Ultrasnon (in press)

  12. Minagawa, T., Kato, H., Ogawa,T., Uehara, T., Ishizuka, O.: Usefulness of
    sonourethrography for penile abscess due to xanthogranulomatous granuloma in
    corpus cavernosum of an adult: a case report. Int.J.Urol. 22: 788-790, 2015.

  13. Yokoyama, H., Domen, T., Hiragata, S., Ogawa, T., Matsumoto,T., Ishizuka, O.:
    Postoperative Mycoplasma hominis infection after robot-assisted laparoscopic radical
    prostatectomy: a case report. Asian J Endosc Surg 9(2):146-148, 2016.

  14. Minagawa, T., Fukui, D., Shingu, K., Ogawa,T., Okada, K., Ishizuka, O.: Intraoperative detection of inferior vena caval tumor thrombus extending from metastatic lymph node of renal cell carcinoma using ultrasonography. J Med Ultrason 11(2): 4-10, 2019.

Review Articles

  1. Mizusawa,H., Ishizuka,O., Nishizawa,O.: Penile hemodynamics in experimental
    animals. Asian J Androl 4(3): 225-228, 2002.

  2. Ishizuka,O., Nishizawa, O., Hirao, Y., Ohshima, S.: Evidence-based metaanalysis of
    pharmacotherapy for benign prostatic hyperplasia. Int. J.Urol., 9: 607-612, 2002.

  3. Ishizuka,O., Mizusawa,H., Nishizawa,O.: Effects of dopaminergic agonists for bladder
    function and intracavenous pressure at the spinal level. Asian J Androl 4(4): 287-290,

  4. Ishizuka, O.: New approaches for overactive bladder treatment: Targeting adrenergic
    receptors and neurokinin receptors. Curr.Med.Chem. (現 Central nervous System
    Agents in Medical Chemistry) 3: 43-47, 2003.

  5. Bade, J., Ishizuka, O., Yoshida, M.: Future research needs for the definition/diagnosis of
    interstitial cystitis. Int.J.Urol., 10: S31-34, 2003.

  6. Imamura, T., Kinebuchi, Y., Ishizuka, O., Seki, S., Igawa, Y., Nishizawa, O.:
    Three-dimensional culture system for differentiation of mice embryonic stem cell into hepatocyte-like cells. J.Organ Dysfunction, 4: 57-64, 2008.

  7. Nishizawa, O., Ishizuka, O., Okamura, K., Gotoh, M., Hasegawa, T., Hirao, Y.:
    Guidelines for management of urinary incontinence. Int.J.Urol., 15: 857-874, 2008.

  8. Imamura, T., Ishizuka, O., Yamamoto, T., Gotoh, M., Nishizawa, O.: Bone
    Marrow-derived cells implanted into freeze-injured urinary bladders reconstruct functional smooth muscle layers. LUTS 2(1): 1-10, 2010.

  9. Nishizawa, O., Araki, I., Ishizuka, O., Uchimura, N., Oh-oka, H., Ozono, S., Kakizaki, H., Kasahara, M., Gotoh, M., Sakakibara, R., Shinbo, H., Sugaya, K., Suzuki, Y., Sone, A., Takei, M., Takeda, M., Hirayama, A., Homma, Y., Yamaguchi, O., Yamanishi, T., Yokoyama, O., Yoshida, M.: Guidelines for nocuturia. Int.J.Urol., 17(5): 397-409, 2010.

  10. Homma, Y., Gotoh, M., Yokoyama, O., Masumori, N., Kawauchi, A., Yamanishi, T., Ishizuka, O., Seki, N., Kamoto, T., Nagai, A., Ozono, S. Outline of JUA clinical guidelines for benign prostatic hyperplasia. Int. J. Urol. 18(11): 741-756, 2011.

  11. Homma, Y., Gotoh, M., Yokoyama, O., Masumori, N., Kawauchi, A., Yamanishi, T., Ishizuka, O., Seki, N., Kamoto, T., Nagai, A., Ozono, S. JUA clinical guidelines for benign prostatic hyperplasia. Int. J. Urol. 18(11): e1-33, 2011.

  12. Ishizuka, O., Imamura, T., Nishizawa, O.: Cold stress and urinary frequency. LUTS 4: 67-74, 2012.

  13. Imamura, T., Ishizuka, O., Nishizawa, O.: Autologous bone marrow-derived cells regenerate urethral sphincters. LUTS 4: 87-94, 2012

  14. Nishizawa, O., Ichino, M., Ishikawa, M., Tanabe, T., Suzuki, H., Saito, T., Imamura, T., Ishizuka, O. Videourodynamic examination and tension-free vaginal mesh/transobturatio tape surgery. LUTS 4: 110-113, 2012.

  15. Nishizawa, O., Kato, H., Ishizuka, O.: Advantage of self-tailored mesh for vaginal prolapse. Int. J. Urol. 19: 494-495, 2012.

  16. Ishizuka, O.: Editorial commnet from Dr. Ishizuka to periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress incontinence: report of three initial cases. Int.J.Urol. 19(7): 659, 2012.

  17. Ishizuka, O.:A novel Therrapeutic Aspect for Male LUTS associated with a1-blocker,
    Naftopidil. Symposium Highlight of 2nd APPS, 2012. (ハングル語).

  18. Ishizuka, O., Imamura, T., Kurizaki, Y., Nishizawa, O., Andersson, K-E.: Male lower urinary tract symptoms and 1D-adrenoceptors. Int.J.Urol. 20(1): 73-78, 2013.

  19. Ishizuka, O.: Editorial commnet from Dr. Ishizuka to Effect of intrathecal administration of E-series prostaglandin (EP) 1 receptor antagonist in a cyclophosphamide-induced cystitis rat model. Int.J.Urol. 20(2): 240, 2013.

  20. Ishizuka, O.: Editorial commnet from Dr. Ishizuka to Efficacy of dose increase therapy with 1D/A-adrenoreceptor antagonist naftopidil for the male lower urinary tract symptoms associated with benign prostatic hyperplasia. Int.J.Urol. 20(5): 520, 2013.

  21. Imamura, T., Ishizuka, O., Nishizawa, O.: Cold stress induces lower urinary tract symptoms. Int.J.Urol. 20: 661-669, 2013.

  22. Imamura, T., Ishizuka, O., Nishizawa, O.: Bone Marrow-Derived cells regenerate structural and functional lower urinary tracts. Intech. Open access article. http://dx.doi.org/10.5772/55558

  23. Minagawa, T., Ishizuka, O.: Status of urological Kampo-medicine: a narrative review and future vision. Int.J.Urol. 22(3): 254-63, 2015.

  24. Ogawa, T., Imamura, T., Nakazawa, M., Hiragata, S., Nagai, T., Minagawa, T., Yokoyama, H., Ishikawa, M., Domen, T., Ishizuka, O.: Transient receptor channel superfamily: Role in lower urinary tract function. Int.J.Urol. 22(11): 994-9, 2015.

  25. Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P., Chancellor, M.B., Yoshimura, N.: Current and emerging drugs for interstitial cystitis/bladder pain syndrome (IC/BPS). Expert Opin. Emerging Drugs 20(4): 1-16, 2015.

  26. Ogawa, T., Sakakibara, R., Kuno,S., Ishizuka,O., Kitta,T., Yoshimura, N.: Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy. Nat. Rev. Urol.14:79-89,2017.

  27. Ogawa, T., Ishizuka, O., Ueda, T., Tyagi, P, Chancellor, M.B., Yoshimura, N.: Pharmacological management of interstitial cystitis/bladder pain syndrome and the role cyclosporine and other immunomodulating drugs play. Expert Rev Clin Pharmacol 11(5): 495-505, 2018.

  28. Wyndaele, J.J., Birch, B., Boarau, A., Burks, F., Catrro-Diaz, D., Chartier-Kastler, E., Drake, M., Ishizuka, O., Minagawa, T., Opisso, E., Peters, K., Padilla-Fernandez, B., Reus, C., Sekido, N.: Surgical management of neurogenic bladder after spinal cord injury. World J Urol. 36(10): 1569-1576, 2018.

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