Targeting Neurotrophin and Nitric Oxide Signalling to Promote Recovery and Ameliorate Neurogenic Bladder Dysfunction following Spinal Cord Injury—Mechanistic Concepts and Clinical Implications

04/09/2023 23:29:04

Workshop Schedule

Karl-Erik Andersson
Anthony John Kanai
Christopher Henry Fry
Naoki Yoshimura

Aims & Objectives

90 minutes
Pure and Applied Science / Translational
Spinal Cord Contusion Detrusor-sphincter dyssynergia detrusor overactivity
Urology, Urogynaecology and Female & Functional Urology, Bowel Dysfunction, Pure and Applied Science

Spinal cord injury (SCI) causes impairment of mobility and neurogenic detrusor overactivity (NDO) that contribute to a decreased quality of life. This workshop will describe: i) the current state-of-the-art management of lower urinary tract (LUT) dysfunction associated with SCI; ii) the pathophysiology of this dysfunction; and iii) the therapeutic potential of three pharmacological agents to promote functional LUT recovery after SCI. These agents are: LM11A-31, a neurotrophin receptor modulator; LM22B-10, an agent that promotes neuronal growth; and cinaciguat, a soluble guanlyate cyclase activator that supports repair of spinal lesions. LM11A-31 and cinaciguat have passed human safety tests and may readily transition to clinical trials.