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ICS Background

Prof Michael Raymond Ruggieri
Lewis KAtz School of Medicine at Temple University

ICS 2019

Podium Session 16 Best Basic Science 277 Bladder reinnervation by somatic nerve transfer to pelvic nerve vesical branches does not reinnervate the urethra

ICS 2017

Podium Short Oral Session 4 Regulation of Bladder Contractility 38 Contractility of bladder smooth muscle is preserved after lower spinal cord injury

Podium Short Oral Session 37 Neurourology 726 Canine urinary bladder receives functional innervation from the upper lumbar and lower thoracic spinal cord after sacral root transection


ICS 2016

Podium Short Oral Session 6 Neurophysiology and Pharmacology 65 Bladder reinnervation by nerve transfer using a primarily motor donor nerve (femoral nerve branches) induces increased sympathetic bladder innervation

ICS 2015

Podium Session 36 Sensation and the Central Nervous System 513 Evidence for bladder fullness sensation in the new neuronal pathway established by genitofemoral or femoral nerve transfer to an anterior vesical pelvic nerve branch in a canine decentralized bladder model.

ICS 2014

Podium Session 28 Neurourology 406 Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder.

ICS 2013

Podium Poster Session 5 Basic Science 2: Sensory Pathways 25 Neuromuscular Nicotinic Receptors Mediate Bladder Contractions Following Reinnervation with Geniotofemoral to Pelvic Nerve Transfer



Non Discussion Poster Session 31 353 Urothelial spermidine release attenuates detrusor muscle contraction.

Non Discussion Poster Session 31 711 Reinnervation of the urethral and anal sphincters with anterior femoral to pudendal nerve transfer

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Michael Ruggieri


Qualifications:PhD Professor
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  1. Gomez-Amaya, S.M., Barbe, M.F., de Groat, W.C., Brown, J.M., Tuite, H.J., Corcos, J., Fecho, S.B., Braverman, A.S. and Ruggieri, Sr., M.R. Neural reconstruction methods of restoring bladder function. doi: 10.1038/nrurol.2015.4, Nature Reviews Urology, 12(2), 100-118, 2015, NIHMSID: 657849, PMID:25599724, PMCID: 4324509.
  2. Gomez-Amaya, S.M. ,Barbe, M.F., Brown, J.M., Lamarre, N.S., Braverman, A.S., Massicotte, V.S. and Ruggieri, Sr., M.R. Bladder reinnervation using a primarily motor donor nerve (femoral nerve branches) is functionally superior to using a primarily sensory donor nerve (genitofemoral nerve). J Urology, 193, 1042, 2015. NIHMSID: 614788, PMID: 25066874, PMCID: 4305355.
  3. Gomez-Amaya, S.M., Barbe, M.F., Lamarre, N.S., Brown, J.M., Braverman, A.S., and Ruggieri, Sr., M.R. Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection. doi: 10.1016/j.juro.2014.10.046. NIHMSID: 657825, PMCID: 4400216, PMID: 25444958; J Urology, 193(6): 2138–2145, 2015.
  4. Izzo, A.A., Muccioli, G.G., Ruggieri, Sr, M.R. and Schicho, R. Endocannabinoids in the digestive tract and bladder in health and disease. R. Pertwee (ed.), Endocannabinoids, doi: 10.1007/978-3-319-20825-1_15. PMID: 26408170, Handbook Exp. Pharmacol., 2015;231:423-47.
  5. Miller, L.S., Vegesna, A.K., Braverman,. A.S. and Ruggieri, M.R. Normal and abnormal physiology, pharmacology, and anatomy of the gastroesophageal junction high-pressure zone. doi: 10.1111/nyas,13168, PMID:2746732, Annals NY Acad. Sci., Issue: The Esophagome, 1380 (1), 48-57, 2016.
  6. Barbe, M.F., Gomez-Amaya, S., Braverman, A.S., Brown, J.M., Lamarre, N., Massicotte, V. Lewis, J.K.S., Dachert, D.R., and Ruggieri, M.R., Sr. Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder. doi: 10.1002/nau.22904. NIHMSID: 749170, PMCID: 4826634, PMID: 26452068; Neurourology and Urodynamics, 36(1):91-7 2017.
  7. Lam Van Ba, O, Barbe, M.F., Caremel. R., Aharony, S, Loutochin, O., Line, J., Wood, M.W., Tiwari, E., Tuite, G.F., Campeau, L, Ruggieri, M.R. and Corcos, J. Lumbar to sacral root rerouting to restore bladder function in a feline spinal cord injury model: Urodynamic and retrograde nerve tracing results from a pilot study. doi: 10.1002/nau.23394, NIHMSID: 910256, PMCID: 5785433, PMID:29314212, Neurourology and Urodynamics, 37(1):153-162, 2018.
  8. Barbe, M.F., Gomez-Amaya, S.M., Salvadeo, D.M., Lamarre, N.S., Cook, S, Glair, C.P., Jang, D.H., Ragheb, R.M., Sheth, A., Braverman, A.S. and Ruggieri, Sr., M.R. Clarification of the Innervation of Genitourinary Structures: A Neuronal Tracing Study in Female Mongrel Hound Dogs. doi: 10.1002/ar.23808, PMID:2957569, PMCID: PMC5143244. The Anatomical Record, 301:1426-1441, 2018.
  9. Salvadeo, D.M., Tiwari, E., Mazzei, M., Brown, J.M., Braverman, A.S., Barbe, M.F. and Ruggieri, Sr., M.R. Determining integrity of bladder innervation and smooth muscle function one year after lower spinal root transection in canines. https://doi.org/10.1002/nau.23765, NIHMSID: 985091, PMID:30024057, PMCID: PMC6202207. Neurourology and Urodynamics, 37, 2495-2501, 2018.
  10. Tiwari, E., Barbe, M.F., Lemay, M.A., Salvadeo, D.M., Wood, M.W., Mazzei, M., Delalic, Z.J., Braverman, A.S and Ruggieri, Sr., M.R. Acute bladder decentralization in hound dogs: Preliminary results of effects on hypogastric nerve electroneurograms and detrusor pressure responses to spinal root and hypogastric nerve stimulation. oi: 10.1371/journal.pone.0215036, PMID: 30970000, PMCID: 6457673.https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215036 PLOS ONE 14(4): e0215036, 2019.
  11. Tiwari, E., Salvadeo, D.M., Braverman, A.S., Frara, N.A., Hobson, L. Cruz, G., Brown, J.M., Pontari, M.A., White, A.R., Barbe, M.F., and Ruggieri, Sr., M.R. Nerve transfer for restoration of lower motor neuron-lesioned bladder and urethra function: establishment of a canine model and interim pilot study results. Journal of Neurosurgery: Spine, https://thejns.org/spine/view/journals/j-neurosurg-spine/aop/article-10.3171-2019.8.SPINE19265/article-10.3171-2019.8.SPINE19265.xml?rskey=BF3zVV Published online November 8, 2019; DOI: 10.3171/2019.8.SPINE19265, vol 32:258-268, 2020.
  12. Roberts MWG, Sui G, Wu R, Rong, W, Wildman S, Montgomery B, Ali A, Langley S, Ruggieri, Sr. MR and C Wu., TRPV4 receptor as a functional sensory molecule in bladder urothelium –stretch-independent, tissue-specific actions and pathological implications, https://doi.org/10.1096/fj.201900961RR, FASEB Journal; 34: 263-286, 2020.
  13. Barbe, M.F., Braverman, A.S., Salvadeo, D.M., Gomez-Amaya, S.M., Lamarre, N.S., Brown, J.M., De. E.J., McIntyre, B.S., Day, E.P., Cruz, G.E., Frara, N. and Ruggieri, Sr., M.R. Bladder reinnervation by somatic nerve transfer to pelvic nerve vesical branches does not reinnervate the urethra. https://doi.org/10.1002/nau.24217, Neurourology and Urodynamics, 39: 181-189, 2020.
  14. Javed, E., Thangavel, C., Frara, N., Singh, J., Mohanty, I., Hypolite, J, Birbe, R., Braverman, A., Den, R., Rattan, S., Deshpande, D., Penn, R., Ruggieri, M., Chacko, S., Boopathi, E. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2. https://doi.org/10.1096/fj.201901301R, FASEB Journal, 34:2126–2146, 2020.
  15. Deshmukh, D.A., Brown, L., Barbe, M.F., Braverman, A.S., Tiwari, E., Hobson, L., Shunmugam, S., Armitage, O., Hewage, E., Ruggieri, Sr., M.R., Morizio, J. Fully Implantable Neural Recording and Stimulation Interfaces: Peripheral Nerve Interface Applications. Journal of Neuroscience Methods, https://www.sciencedirect.com/science/article/pii/S0165027019304194?via%3Dihub, Volume 333, 108562, 1 March 2020.

Prof Michael Raymond Ruggieri declared on the Wednesday 27th January 2021 that they had the following existing or known future financial relationships or affiliations:

Karl Storz Endoskope

  • Research grant